Project Details
Projekt
Structural and functional organization of endocytic scaffolds within the periactive zone (A01)
Subject Area
Cell Biology
Term
from 2011 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641
We have shown that synaptic vesicles (SVs) are recycled via clathrin-independent actin-mediated endocytosis. Using cell biological and (opto-)genetic approaches together with super-resolution microscopy and modeling we will now dissect how actin-nucleation by formins regulates actomyosin activity to facilitate SV membrane retrieval, how these activities are coordinated with the acquisition of membrane curvature via BAR-domain proteins, and how SVs are reformed from endosomal-like vacuoles by the endocytic scaffolds intersectin 1 and 2.
DFG Programme
Collaborative Research Centres
Applicant Institution
Freie Universität Berlin
Project Heads
Professor Volker Haucke, Ph.D.; Professorin Dr. Tanja Maritzen
