GRK 1422:  Metal Sites in Biomolecules: Structures, Regulation and Mechanisms

• Subject Area: Biological Chemistry and Food Chemistry ; Basic Research in Biology and Medicine
• Term: from 2006 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 20170465

• Final Report Year: 2016

Final Report Abstract

Almost half of all proteins contain a metal cofactor, and it is well recognized that these metallobiomolecules are of key importance for a large number of biological reactions and phenomena. Furthermore, the interaction of metal ions with biomolecules is important for the field of medicinal inorganic chemistry, since metal complexes have become viable candidates for diagnostics and therapeutics. A detailed understanding of the molecular mechanisms of metallobiosite function is thus of great interest, but requires a comprehensive interdisciplinary approach at the interface of chemistry and biology. To this end, a consortium of 7 – 10 research groups from the Georg-August-University Göttingen, Germany, and 7 research groups from the University of Lund, Sweden, teamed up in the IRTG 1422 to investigate the structures, the regulation and the function of natural and artificial metallobiosites, and to emulate these structures and their functions by small biomimetic or bioinspired model systems. The scientists comprised chemists, biologists and biophysicists with both experimental and theoretical approaches. Importantly, the IRTG provided a stimulating environment for young researchers, where they could gain profound methodological knowledge of different techniques and acquire the necessary skills for cutting-edge research in the challenging field of bioinorganic chemistry. The qualification program of the IRTG offered an attractive and wide range of scientific and soft skill training with pronounced international accentuation. Specific method courses addressed the interdisciplinary nature of the research projects and annual workshops, several of them organized as a joint events with other research consortia, created a unique team spirit. The IRTG 1422 aimed at combining adequate supervision and guidance by thesis committees with the promotion of scientific independence of the young researchers. Active involvement of doctoral students in shaping the program was a key feature of the IRTG 1422. In Göttingen, the IRTG established a structures PhD program “BioMetals” in the framework of the Georg-August-University School of Science (GAUSS). Over the full funding period 2006 – 2015, 8 young research group leaders contributed as principle investigators. All of them received offers for professorship positions while being members of the IRTG, indicating that the IRTG provided a stimulating environment for their successful career development. Over the full 9-years funding period 56 doctoral students and 5 postdoctoral fellows in Göttingen were members of the IRTG. Scientific achievements are documented in a total of 211 research publications (co)authored by doctoral and postdoctoral researchers of the IRTG which have appeared during the period 2007 – 2016. A bioinorganic chemistry conference in Lund in 2014 and the final IRTG symposium in Göttingen in 2015, both with a line-up of renowned international guest speakers, served to showcase the research achievements of the IRTG.

Publications

• Different Coordination Chemistry of Molybdenum and Tungsten – Reactions of the Dichloro Dioxo Complexes with Thiolate. Inorg. Chim. Acta 2007, 360, 3400-3407
  Q. Zhang, K. Starke, C. Schulzke, A. Hofmeister, J. Magull
  
• Oligonuclear copper complexes of a bioinspired pyrazolate-bridging ligand: synthesis, structures and equilibria in solution. Inorg. Chem., 2007, 46, 4298-4307
  A. Prokofieva, A. I. Prikhod’ko, E. A. Enyedy, E. Farkas, W. Maringgele, S. Demeshko, S. Dechert, F. Meyer
  
• Relatively stable N-ligated [2Fe2S]2+ clusters with dipyrromethane capping ligands. J. Inorg. Biochem. 2007, 101, 305-312
  J. Ballmann, X. Sun, S. Dechert, E. Bill, F. Meyer
  
• Synthese und DFT-Studien von Modellkomplexen molybdopterinhaltiger Enzyme, Universität Göttingen, 2007
  K. Starke
  
• A Synthetic Analogue of Rieske-Type [2Fe-2S] Clusters. Angew. Chem. 2008, 120, 9680-9684; Angew. Chem. Int. Ed. 2008, 47, 9537-9541
  J. Ballmann, A. Albers, S. Demeshko, S. Dechert, E. Bill, E. Bothe, U. Ryde, F. Meyer
  
• An unusually stable octanuclear sigma-mesityl-bridged mu4- oxo-copper(I) complex encapsulated by a pyrazolate-based compartmental ligand scaffold. Chem. Commun. 2008, 1744-1746
  M. Stollenz, C. Große, F. Meyer
  
• Binding and reduction of sulfite by cytochrome c nitrite reductase. Biochemistry 2008, 47, 2080-2086
  P. Lukat, M. Rudolf, P. Stach, A. Messerschmidt, P.M. Kroneck, J. Simon, O. Einsle
  
• Bioinspired oxidation reactions of phenols with dinuclear copper complexes, Universität Göttingen, 2008
  A. Prokofieva
  
• Crystal packing of the c(6)-type cytochrome OmcF from Geobacter sulfurreducens is mediated by an N-terminal Strep-tag II. Acta Cryst. D Biol. Crystallogr. 2008, 64, 919-926
  P. Lukat, M. Hoffmann, O. Einsle
  
• Formation of a Titanium Complex with a Ti=CHAl2 Structural Unit from LTiMe3 and Trimethylaluminum. Organometallics 2008, 27, 2544–2548
  G. B. Nikiforov, H. W. Roesky, B. C. Heisen, C. Große, R. B. Oswald
  
• Guanosine Analog with Respect to Z-DNA Stabilization: Nucleotide with Combined C8-Bromo and C2’-Ethinyl Modifications. Eur. J. Org. Chem., 2008, 1544-1549
  A. Nadler, U. Diederichsen
  
• New Biomimetic Analogues of Functional [2Fe-2S] Proteins, Universität Göttingen, 2008
  H.-J. Ballmann
  
• Properties of a mini 9R-lipoxygenase from Nostoc sp. PCC 7120 and its mutant forms. Phytochemistry 2008, 69, 1832-1837
  A.-Z. Andreou, M. Vanko, L. Bezakova, I. Feussner
  
• Secondary Bonding Interactions in Biomimetic [2Fe-2S] Clusters. Inorg. Chem. 2008, 47, 1586-1598
  J. Ballmann, S. Dechert, E. Bill, U. Ryde, F. Meyer
  
• Selective benzylic C-C coupling catalyzed by a bioinspired dicopper complex, "Hot Articles" section, Chem. Commun., 2008, 8, 1005-1007
  A. Prokofieva, A. I. Prikhod’ko, S. Dechert, F. Meyer
  
• Stereoselective synthesis of 4- dehydroxydiversonol employing enantioselective palladium-catalysed domino reactions. Chem. Eur. J. 2008, 14, 8956-8963
  L. F. Tietze, D. A. Spiegl, F. Stecker, J. Major, C. Raith, C. Große
  
• A convenient ligand exchange pathway to [2Fe-2S] ferredoxin analogues. Dalton Trans. 2009, 4908 - 4917
  J. Ballmann, X. Sun, S. Dechert, B. Schneider, F. Meyer
  
• Biomimetic and Theoretic Investigation of Unusual Iron-Sulfur Clusters, Universität Göttingen, 2009
  M. Fuchs
  
• Biosynthesis of oxylipins in non-mammals. Prog Lipid Res 2009, 48, 148-170
  A. Andreou, F. Brodhun, I. Feussner
  
• Crystallographic ab initio protein structure solution below atomic resolution. Nat Methods. 2009, 6, 651-653
  D. D. Rodríguez, C. Große, S. Himmel, C. González, I. M. de Ilarduya, S. Becker, G. M. Sheldrick, I. Usón
  
• Histidine Analog Amino Acids Providing Metal Binding Sites derived from Bioinorganic Model Systems. Eur. J. Org. Chem., 2009, 4593-4599
  A. Nadler, C. Hain, U. Diederichsen
  
• Identification of PpoA from Aspergillus nidulans as a fusion protein of a fatty acid heme dioxygenase/peroxidase and cytochrome P450. J. Biol. Chem. 2009, 284, 11792-11805
  F. Brodhun, C. Göbel, E. Hornung, I. Feussner
  
• Insertion Reaction of a Silylene into a N-H Bond of Hydrazine and a [1+4] Cycloaddition with Diphenyl Hydrazone. Organometallics 2009, 28, 6574-6577
  A. Jana, H. W. Roesky, C. Schulzke, P. P. Samuel
  
• Lipoxygenases - Structure and reaction mechanism. Phytochemistry 2009, 70, 1504-1510
  A. Andreou, I. Feussner
  
• Oligonuclear homoleptic copper(I) pyrazolates with multinucleating ligand scaffolds: high structural diversity in solidstate and solution. Inorg. Chem. 2009, 48, 10049-10059
  M. Stollenz, M. John, H. Gehring, S. Dechert, C. Große, F. Meyer
  
• On the Substrate Binding of Linoleate 9-Lipoxygenases. Lipids 2009, 44, 207-215
  A.-Z. Andreou, E. Hornung, S. Kunze, S. Rosahl, I. Feussner
  
• Oxidative ortho C-C coupling of 4-ethylphenol by dual substrate activation at a bioinspired dicopper complex – trapping of an unusual oligophenolic Cu6 species. Chem. Eur. J. 2009, 15(20), 4994-4997
  A. Prokofieva, C. Groβe, G. M. Sheldrick, F. Meyer
  
• Oxidative ortho C-C coupling of 4-ethylphenol by dual substrate activation at a bioinspired dicopper complex--trapping of an unusual oligophenolic Cu6 species. Chem. Eur. J. 2009, 15, 4994-4997
  A. Prokofieva, S. Dechert, C. Große, G.M. Sheldrick, F. Meyer
  
• Structural Examination of the Transient 3-Aminotyrosyl Radical on the PCET Pathway of E. coli Ribonucleotide Reductase by Multifrequency EPR Spectroscopy. J. Am. Chem. Soc. 2009, 131, 15729-15738
  M.R. Seyedsayamdost, T. Argirević, E.C. Minnihan, J. Stubbe, M. Bennati
  
• Structural Variations in Tetrasilver(I) Complexes of Pyrazolate-bridged Compartmental N-Heterocyclic Carbene Ligands. Z. Naturforsch. 2009, 64b, 1542-1552
  M. Georgiou, S. Wöckel, V. Konstanzer, S. Dechert, M. John, F. Meyer
  
• Synthesis and Coordination Properties of Chelating Dithiophenolate Ligands. Inorg. Chem. 2009, 48, 90-99
  J. Ballmann, M.G.G. Fuchs, S. Dechert, M. John, F. Meyer
  
• Tuning Electronic Properties of Biomimetic [2Fe-2S] Clusters by Ligand Variations. Eur. J. Inorg. Chem. 2009, 3219-3225
  J. Ballmann, S. Dechert, S. Demeshko, F. Meyer
  
• Which functional groups of the molybdopterin ligand should be considered when modeling the active sites of the molybdenum and tungsten cofactors? - a DFT study. J. Biol. Inorg. Chem. 2009, 14, 1053-1064
  U. Ryde, C. Schulzke, K. Starke
  
• A bisallylic mini-lipoxygenase from cyanobacterium Cyanothece sp. that has an iron as cofactor. J. Biol. Chem. 2010, 285, 14178-14186
  A. Andreou, C. Göbel, M. Hamberg, M., I. Feussner
  
• A combined computational and experimental investigation of the [2Fe-2S] cluster in biotin synthase. J. Biol. Inorg. Chem. 2010, 15, 203-212
  M. G. G. Fuchs, F. Meyer, U. Ryde
  
• A Five-Coordinate [2Fe-2S] Cluster. Inorg. Chem. 2010, 49, 5853-5858
  M. G. G. Fuchs, S. Dechert, S. Demeshko, U. Ryde, F. Meyer
  
• A rational design for an efficient synthesis of a monomeric tin(II) hydroxide. Chem. Commun. 2010, 46, 707-709
  A. Jana, S. P. Sarish, H. W. Roesky, C. Schulzke, P. P. Samuel
  
• An efficient route for the synthesis of a Tin(II) substituted carbodiimide from a diazo compound. Inorg. Chem. 2010, 49, 3461-3464
  A. Jana, H. W. Roesky, C. Schulzke, P. P. Samuel
  
• Biochemische Charakterisierung von PpoA aus Aspergillus nidulans, Universität Göttingen, 2010
  F. Brodhun
  
• Crystallization of purple nitrous oxide reductase from Pseudomonas stutzeri. Acta Cryst. 2010, F66, 1541-1543
  A. Pomowski, W. G. Zumft, P.M.H. Kroneck, O. Einsle
  
• DNA Bending Molecules for Improvement of Cisplatin Binding, Cuvillier Verlag, Göttingen 2010
  M. S. Damian
  
• Effects in 94 GHz Orientation Selected PELDOR on a Rigid Pair of Radicals with Non-Collinear Axes. Appl. Magn. Reson. 2010, 37, 539-548
  G. Sicoli, T. Argirević, J. Stubbe, I. Tkach, M. Bennati
  
• Investigation of molybdenum iron protein expression and activity in Wolinella succinogenes, Universität Göttingen, 2010
  H. Saad Eddin
  
• N-Coordinated [2Fe-2S] and [4Fe-4S] Clusters: Synthesis, Structures and Spectroscopic Characterisation. Eur. J. Inorg. Chem. 2010, 3247-3251
  M. G. G. Fuchs, S. Dechert, S. Demeshko, F. Meyer
  
• New non-heme iron mini lipoxygenases from prokaryotes, Universität Göttingen, 2010
  A.-Z. Andreou
  
• PpoC from Aspergillus nidulans is a fusion protein with only one active heme. Biochem. J. 2010, 425, 553-565
  F. Brodhun, S. Schneider, E. Hornung, C. Göbel, I. Feussner
  
• Preparation of iron carbonyl complexes of germanium(II) and tin(II) each with a terminal fluorine atom. J. Fluorine Chem. 2010, 131, 1096-1099
  A. Jana, P. P. Samuel, H. W. Roesky, C. Schulzke
  
• Reaction of tin(II) hydride with compounds containing aromatic C−F bonds. Organometallics 2010, 29, 4837-4841
  A. Jana, H. W. Roesky, C. Schulzke, P. P. Samuel
  
• Selective aromatic C–F and C–H bond activation with silylenes of different coordinate silicon. J. Am. Chem. Soc. 2010, 132, 10164-10170
  A. Jana, P. P. Samuel, G. Tavčar, H. W. Roesky, C. Schulzke
  
• Sticky triangles: New tools for experimental phasing of biological macromolecules, Universität Göttingen, 2010
  T. Beck
  
• Strukturelle und funktionelle Untersuchung chemisch modifizierter Oligonucleotide und Peptide, Logos Verlag, Berlin 2010
  A. Nadler
  
• Synthesis and characterization of N-heterocyclic carbene complexes of titanium(IV) and titanium(III). Z. Anorg. Allg. Chem. 2010, 633, 511-514
  J. Li, C. Schulzke, S. Merkel, H. W. Roesky, P. P. Samuel, A. Döring, D. Stalke
  
• Synthesis and DNA Interaction of Platinum Complex/Peptide Chimera as Potential Drug Candidates. Eur. J. Org. Chem. 2010, 6161-6170
  M. S. Damian, H. K. Hedman, S. K. C. Elmroth, U. Diederichsen
  
• Synthesis and reaction of monomeric germanium(II) and lead(II) dimethylamide and the synthesis of germanium(II) hydrazide by cleavage of one N–H bond of hydrazine. Inorg. Chem. 2010, 49, 5554-5559
  A. Jana, H. W. Roesky, C. Schulzke, P. P. Samuel, A. Döring
  
• Synthesis of 8,1’-ethano bridged guanosine derivatives using radical cyclization. Heterocycles 2010, 82, 713-728
  J. Strohmeier, A. Nadler, D. Heinrich, A. Fitzner, U. Diederichsen
  
• Synthesis of phosphine substituted β-diketiminate based isomeric Ge(II). Dalton Trans. 2010, 39, 234-238
  N.D. Reddy, A. Jana, H.W. Roesky, P.P. Samuel, C. Schulzke
  
• Synthesis, structure and Mössbauer characterization of polymeric iron(II) complexes with bidentate thiourea ligands. Inorg. Chim. Acta 2010, 363, 3088–3092
  S. Meyer, S. Demeshko, S. Dechert, F. Meyer
  
• Unsymmetrical dizinc complexes as models for the active sites of phosphohydrolases. Dalton Trans. 2010, 39, 8183-8194
  M. Jarenmark, E. Csapó, J. Singh, S. Wöckel, E. Farkas, F. Meyer, M. Haukka, E. Nordlander
  
• 8-Vinyl-2’-deoxyguanosine as Fluorescent 2’- Deoxyguanosine Mimic for Investigating DNA Hybridization and Topology. Angew. Chem. 2011, 123, 5504-5508; Angew. Chem. Int. Ed. 2011, 50, 5392-5396
  A. Nadler, J. Strohmeier, U. Diederichsen
  
• A Crystallographic and Mo K-Edge XAS Study of Molybdenum Oxo Bis-, Mono-, and Non-Dithiolene Complexes – First-Sphere Coordination Geometry and Noninnocence of Ligands. Eur. J. Inorg. Chem. 2011, 2011, 4387-4399
  P.P. Samuel, S. Horn, A. Döring, K.G.V. Havelius, S. Reschke, S. Leimkühler, M. Haumann, C. Schulzke
  
• From pyrazolate-based binuclear copper(I) complexes to octanuclear σ-mesityl-bridged μ4-oxocuprocuprates: controlled dioxygen splitting by organocopper scaffolds. Organometallics 2011, 30, 3708-3725
  M. Stollenz, H. Gehring, V. Konstanzer, S. Fischer, S. Dechert, C. Große, F. Meyer
  
• Influence of substrate dideuteration on the reaction of the bifunctional heme enzyme psi factor producing oxygenase A (PpoA). ChemBioChem 2011, 12, 728-737
  A. Nadler, C. Koch, F. Brodhun, J. Wehland, K. Tittmann, I. Feussner, U. Diederichsen
  
• Integrated anaylsis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy. J. Biomol. NMR 2011, 49, 111-119
  T. Grüne, M.-K. Cho, I. Karyagina, H.-Y. Kim, C. Große, K. Giller, M. Zweckstetter, S. Becker
  
• Molybdenum and tungsten compounds with dithiolene ligands inspired by molybdopterin as models for the molybdenum and tungsten cofactors, Universität Göttingen, 2011
  P. P. Samuel
  
• Multifrequency electron paramagnetic resonance characterization of PpoA, a CYP450 fusion protein that catalyses fatty acid dioxygenation. J. Am. Chem. Soc. 2011, 133, 9052-9062
  A. J. Fielding F. Brodhun, C. Koch, R. Pievo, V. P. Denysenkov, I. Feussner, M. Bennati
  
• Multinuclear Pyrazolate-Based Copper Complexes Inspired by the CuZ-Site of N2O-Reductase, Cuvillier Verlag, Göttingen 2011
  V. Konstanzer
  
• N2O binding at a [4Cu:2S] copper-sulphur cluster in nitrous oxide reductase. Nature 2011, 477, 234-237
  A. Pomowski, W.G. Zumft, P.M.H. Kroneck, O. Einsle
  
• Optimising His-tags for purification and phasing, Universität Göttingen, 2011
  C. Große
  
• Oxylipins in fungi. FEBS J. 2011, 278, 1047-1063
  F. Brodhun, I. Feussner
  
• Reactions of Stable Amidinate Chlorosilylende and [1+4]-Oxidative Addition of N-Heterocyclic Silylene with N-Benzylideneaniline. Eur. J. Inorg. Chem. 2011, 5006-5013
  A. Jana, R. Azhakar, S. P. Sarish, P. P. Samuel, H. W. Roesky, C. Schulzke, D. Koley
  
• Structural characterization of the two copper proteins nitrous oxide reductase from Pseudomonas stutzeri and laccase Lcc5 from Coprinopsis cinerea, Universität Göttingen, 2011
  A. Pomowski
  
• Structural investigations on the Fe(II)/α-ketoglutarate dependent dioxygenase PlaO1 from Streptomyces sp., Universität Freiburg, 2011
  P. Lukat
  
• Syntheses and Analyses of Modified Zif268 Zinc Finger Domains, Books on Demand, Berlin 2011
  F. Fehr
  
• Synthesis and Characterization of Di- and Tetracarbene Iron(II) Complexes with Chelating N-Heterocyclic Carbene Ligands and Their Application in Aryl Grignard – Alkyl Halide Cross-Coupling. Organometallics 2011, 30, 6692–6702
  S. Meyer, C. M. Orben, S. Demeshko, S. Dechert, F. Meyer
  
• Synthesis of a Lewis Base Stabilized Dimer of N-Substituted Hydrosila Hydrazone and a Silaaziridine. Organometallics 2011, 30, 912-916
  S.P. Sarish, A. Jana, H.W. Roesky, P.P. Samuel, C.E.A. Andrade, B. Dittrich, C. Schulzke
  
• Synthetic Models for Dizinc Metallohydrolases, Universität Göttingen, 2011
  S. Wöckel
  
• The alphabet of galactolipids in Arabidopsis thaliana. Front. Plant Sci. 2011, 2, 95
  A. Ibrahim, A.-L. Schütz, J.-M. Galano, C. Herrfurth, K. Feussner, T. Durand, F. Brodhun, I. Feussner
  
• Triostin A derived hybrid for simultaneous DNA binding and metal coordination. Amino Acids 2011, 41, 449-456
  E.-F. Sachs, A. Nadler, U. Diederichsen
  
• Visualising the carboxylate shift at a bioinspired diiron(II) site in solid state. Chem. Commun. 2011, 47, 10428-10430
  B. Burger, S. Dechert, C. Große, S. Demeshko, F. Meyer
  
• Binding of β-Lactam Antibiotics to a Bioinspired Dizinc Complex Reminiscent of the Active Site of Metallo-ß-lactamases. Inorg. Chem. 2012, 51, 2486-2493
  S. Wöckel, J. Galezowska, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1021/ic202425m)
• Biosynthesis of allene oxides in Physcomitrella patens. BMC Plant Biol. 2012, 12, 228
  J. Scholz, F. Brodhun, E. Hornung, C. Herrfurth, M. Stumpe, A. K. Beike, B. Faltin, W. Frank, R. Reski, I. Feussner
  (See online at https://doi.org/10.1186/1471-2229-12-228)
• Convenient Synthetic Route to Palladium Complexes of Unconventional N-Heterocyclic Carbenes Derived from Pyridazine and Phthalazine. Organometallics 2012, 31, 8537–8543
  T. Guo, S. Dechert, S. Meyer, F. Meyer
  (See online at https://doi.org/10.1021/om300899r)
• Crystal structures of Physcomitrella patens AOC1 and 2: Insights into the enzyme mechanism and differences in substrate specificity. Plant Physiol. 2012, 160, 1251-1266
  P. Neumann, F. Brodhun, K. Sauer, C. Herrfurth, M. Hamberg, J. Brinkmann, J. Scholz, A. Dickmanns, I. Feussner, R. Ficner
  (See online at https://doi.org/10.1104/pp.112.205138)
• ENDOR spectroscopy and DFT calculations: Evidence for the hydrogen-bond network within α2 in the PCET of E. Coli ribonucleotide reductase. J. Am. Chem. Soc. 2012, 134, 17661-17670
  T. Argirević, C. Riplinger, J. Stubbe, F. Neese, M. Bennati
  (See online at https://doi.org/10.1021/ja3071682)
• Gold(I), Gold(III), and Heterometallic Gold(I)– Silver(I) and Gold(I)–Copper(I) Complexes of a Pyridazine-Bridged NHC/Pyrazole Hybrid Ligand and Their Initial Application in Catalysis. Organometallics 2012, 31, 5025–5033
  J. Wimberg, S. Meyer, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1021/om300335w)
• High-field EPR and ENDOR spectroscopy for proton-coupled electron transfer investigations in E.coli ribonucleotide reductase, Universität Göttingen, 2012
  T. Argirevic
  
• Influence of Donor-Acceptor Distance Variation on Photoinduced Electron and Proton Transfer in Rhenium(I)-Phenol Dyads. J. Am. Chem. Soc . 2012, 134, 12844-12854
  M. Kuss-Petermann, H. Wolf, D. Stalke, O. S. Wenger
  (See online at https://doi.org/10.1021/ja3053046)
• Linoleic acid positioning in psi factor producing oxygenase A, a fusion protein with an atypical cytochrome P450 activity. FEBS 2012, 279, 1594-1606
  C. Koch, A.J. Fielding, F. Brodhun, M. Bennati, I. Feussner
  (See online at https://doi.org/10.1111/j.1742-4658.2011.08352.x)
• Linoleic acid positioning in Psi-factor oxygenase A, a fusion protein with a atypical cytochrome P450-activity. FEBS J. 2012, 279, 1594-1606
  C. Koch, A. J. Fielding, F. Brodhun, M. Bennati, I. Feussner
  
• Nature’s way of handling a greenhouse gas: The copper-sulfur cluster of purple nitrous oxide reductase. Biol. Chem. 2012, 393, 1067-1077
  A. Wüst, L. Schneider, A. Pomowski, W. G. Zumft, P.M.H. Kroneck, O. Einsle
  (See online at https://doi.org/10.1515/hsz-2012-0177)
• New Structural and Functional Synthetic Analogues for [2Fe-2S] Rieske Clusters, Dr. Hut Verlag, München 2012
  A. Albers
  
• Phenalenyl-Based Organozinc Catalysts for Intramolecular Hydroamination Reactions: A Combined Catalytic, Kinetic, and Mechanistic Investigation of the Catalytic Cycle. Chem. Eur. J. 2012, 18, 10530-10545
  Mukherjee, T.K. Sen, P.K. Ghorai, P.P. Samuel, C. Schulzke, S.K. Mandal
  (See online at https://doi.org/10.1002/chem.201200868)
• Reversible Solvatomagnetic Effect in Novel Tetranuclear Cubane-Type Ni4 Complexes and Magnetostructural Correlations for the [Ni4(μ3-O)4] Core. Inorg. Chem. 2012, 51, 8141–8149
  A. Das, F. J. Klinke, S. Demeshko, S. Meyer, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1021/ic300535d)
• Semi-Synthesis and Analysis of chemically modified Zif268 Zinc Finger Domains. ChemistryOpen 2012, 1, 26-32
  F. Fehr, A. Nadler, F. Brodhun, I. Feussner, U. Diederichsen
  (See online at https://doi.org/10.1002/open.201100002)
• Structure, Dynamics and Bioinspired Reactivity of Novel Pyrazolate-based Diiron Complexes, Dr. Hut Verlag, München 2012
  B. Burger
  
• The Carboxylate Twist: Hysteretic Bistability of a High-Spin Diion(II) Complex Identified by Mössbauer Spectroscopy. Angew. Chem. 2012, 124 10190-10195; Angew. Chem. 2012, 51, 10045-10049
  B. Burger, S. Demeshko, E. Bill, S. Dechert, F. Meyer
  
• Zinc Complexes of Bioinspired Binucleatic Ligand Platform - Equilibria in Solution and Structures in the Solid State. Eur. J. Inorg. Chem. 2012, 4728-4738
  S. Wöckel, J. Galezowska, S. Dechert, W. Meyer-Klaucke, E. Nordlander, F. Meyer
  (See online at https://doi.org/10.1002/ejic.201200269)
• A Functional Model for the Rieske Center: Full Characterization of a Biomimetic N-Ligated [2Fe–2S] Cluster in Different Protonation States. Chem. Eur. J. 2013, 19, 10101–10106
  A. Albers, T. Bayer, S. Demeshko, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1002/chem.201301760)
• A rapid freeze-quench setup for multi-frequency EPR spectroscopy of enzymatic reactions. ChemPhysChem 2013, 14, 4094-4101
  R. Pievo, B. Angerstein, A. J. Fielding, C. Koch, I. Feussner, M. Bennati
  (See online at https://doi.org/10.1002/cphc.201300714)
• A structural model of PpoA derived from SAXS-analysis--Implications for substrate conversion. Biochim. Biophys. Acta 2013, 1831, 1449-1457
  C. Koch, G. Tria, A.J. Fielding, F. Brodhun, O. Valerius, K. Feussner, G.H. Braus, D.I. Svergun, M. Bennati, I. Feussner
  (See online at https://doi.org/10.1016/j.bbalip.2013.06.003)
• A Tetracarbene-Oxoiron(IV) Complex. Angew. Chem. 2013, 125, 935–939; Angew. Chem. Int. Ed. 2013, 52, 901–905
  S. Meyer, I. Klawitter, S. Demeshko, E. Bill, F. Meyer
  
• An iron 13S- lipoxygenase with an α-linolenic acid specific hydroperoxidase activity from Fusarium oxysporum. PLoS ONE 2013, 8, e64919
  F. Brodhun, A. Cristobal-Sarramian, S. Zabel, J. Newie, M. Hamberg, I. Feussner
  (See online at https://doi.org/10.1371/journal.pone.0064919)
• Design and Characterisation of Multifunctional Tools for the Elucidation of the Cu+ Chemistry in Alzheimer`s Disease, Universität Göttingen, 2013
  M. Rittmeier
  
• Extending the scope of protein synthesis by a novel auxiliary‐based Native Chemical Ligation strategy, Cuvillier Verlag, Göttingen 2013
  C. Nadler
  
• Identification and characterization of an oleate hydrataseencoding gene from Bifidobacterium breve. Bioengineered 2013, 4, 1-9
  K. J. O’Connell, M. Motherway, A. A. Hennessey, F. Brodhun, R. P. Ross, I. Feussner, C. Stanton, G. F. Fitzgerald, D. Van Sinderen
  (See online at https://doi.org/10.4161/bioe.24159)
• Mechanistic Diversity in Proton-Coupled Electron Transfer between Thiophenols and Photoexcited [Ru(2,2'-Bipyrazine)3]2+. J. Phys. Chem. Lett. 2013, 4, 2535-2539
  M. Kuss-Petermann, O. S. Wenger
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• New Tripodal Tridentate Ligands with {NS2} Donor Set and a Backbone Hydroxo Anchor, and Their Copper(I) and Copper(II) Complexes. Z. Allg. Anorg. Chem. 2013, 639, 1445-1454
  M. Rittmeier, S. Dechert, S. Demeshko, F. Meyer
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• Nickel(II) and Iron(II) Complexes with Tetradentate NHC/Amide Hybrid Ligands. Z. Naturforsch. 2013, 68b, 458–466
  I. Klawitter, S. Meyer, S. Demeshko, F. Meyer
  (See online at https://doi.org/10.5560/ZNB.2013-3091)
• Photoacid Behavior versus Proton-Coupled Electron Transfer in Phenol−Ru(bpy)32+Dyads. J. Phys. Chem A 2013, 117, 5726-5733
  M. Kuss-Petermann, O. S. Wenger
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• Photochemistry between a Ruthenium(II) Pyridylimidazole Complex and Benzoquinone: Simple Electron Transfer versus Proton-Coupled Electron Transfer. Photochem. Photobiol. Sci. 2013, 12, 254-261
  R. Hönes, M. Kuss-Petermann, O. S. Wenger
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• Preorganized Anion Traps for Exploiting Anion-π Interactions – an Experimental and Computational Study. Chem. Eur. J. 2013, 19, 16988–17000
  A. Bretschneider, D. M. Andrada, S. Dechert, S. Meyer, R. A. Mata, F. Meyer
  (See online at https://doi.org/10.1002/chem.201302598)
• Stable and Metastable Self-Assembled Rings based on trans-chelated PdII. Z. Anorg. Allg. Chem. 2013, 639, 1598–1605
  F. A. Pereira, T. Fallows, M. Frank, A. Chen, G. H. Clever
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• Structure and function of A.nidulans PSI factor producing oxygenase A, Universität Göttingen, 2013
  C. Koch
  
• Study of ligand effects in aurophilic interactions using local correlation methods. Phys. Chem. Chem. Phys. 2013, 15, 18115-18122
  M. Andrejić, R. A. Mata
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• Synthesis of spin-labeled riboswitch RNAs using convertible nucleosides and DNA-catalyzed RNA ligation. Bioorg. Med. Chem. 2013, 21, 6171-6180
  L. Büttner, J. Seikowski, K. Wawrzyniak, A. Ochmann, C. Höbartner
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• (2R,1’S,2’R)- and (2S, 1’S, 2’R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl] alanines and their incorporation into hormaomycin analogues. Beilstein J. Org. Chem. 2014, 10, 2844-2857
  A. de Meijere, S. I. Kozhushkov, D. S. Yufit, C. Große, M. Kaiser, V. A. Raev
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• A quantummechanical study of the reaction mechanism of sulfite oxidase. J. Biol. Inorg. Chem. 2014, 19, 1165-1179
  M. van Severen, M. Andrejić, J. Li, K. Starke, R. A. Mata, E. Nordlander, U. Ryde
  (See online at https://doi.org/10.1007/s00775-014-1172-z)
• Biochemical analysis of CYP74-enzymes in Physcomitrella patens, Universität Göttingen, 2014
  J. C. Scholz
  
• Clever: Subtle backbone modifications control the interpenetration of dibenzosuberone-based coordination cages. RSC. Adv. 2014, 4, 29724-29728
  T. R. Schulte, M. Krick, C. I. Asche, S. Freye, G. H.
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• Coupled-Cluster Interaction Energies for 200- Atom Host–Guest Systems. Chem. Phys. Chem. 2014, 15, 3270–3281
  M. Andrejić, U. Ryde, R. A. Mata, P. Söderhjelm
  (See online at https://doi.org/10.1002/cphc.201402379)
• Crowning of Coinage Metal Pyrazolates: Double-Decker Homo- and Heteronuclear Complexes with Synergic Emissive Properties. Inorg. Chem. 2014, 53, 2333–2341
  M. Veronelli, N. Kindermann, S. Dechert, S. Meyer, F. Meyer
  (See online at https://doi.org/10.1021/ic5001792)
• Deoxyribozyme-Mediated Ligation for Incorporating EPR Spin Labels and Reporter Groups into RNA. Methods in Enzymology 2014, 85-104
  K. Wawrzyniak-Turek, C. Höbartner
  (See online at https://doi.org/10.1016/B978-0-12-801122-5.00004-0)
• Distance Dependence of Bidirectional Concerted Proton-Electron Transfer in Phenol-[Ru(2,2'-Bipyridine)3]2+ Dyads. Chem. Eur. J. 2014, 20, 4098-4104
  J. Chen, M. Kuss-Petermann, O. S. Wenger
  (See online at https://doi.org/10.1002/chem.201304256)
• Enzymatic combinatorial nucleoside deletion scanning mutagenesis of functional RNA. Chem. Commun. 2014, 10937-10940
  K. Wawrzyniak-Turek, C. Höbartner
  (See online at https://doi.org/10.1039/c4cc04719b)
• Free-energy perturbation and quantum mechanical study of SAMPL4 octa-acid host–guest binding energies. J. Comput. Aided. Mol. Des. 2014, 28, 375-400
  P. Mikulskis, D. Cioloboc, M. Andrejić, S. Khare, J. Brorsson, S. Genheden, R. A. Mata, P. Söderhjelm, U. Ryde
  (See online at https://doi.org/10.1007/s10822-014-9739-x)
• Functional Model for the [Fe] Hydrogenase Inspired by the Frustrated Lewis Pair Concept. J. Am. Chem. Soc. 2014, 136, 16626–16634
  K. F. Kalz, A. Brinkmeier, S. Dechert, R. A. Mata, F. Meyer
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• Local Hybrid QM/QM Calculations of Reaction Pathways in Metallobiosites. J. Chem. Theory Comput. 2014, 10, 5397–5404
  M. Andrejić, R. A. Mata
  (See online at https://doi.org/10.1021/ct5008313)
• Mimicking the [Fe] Hydrogenase Active Site, Cuvillier Verlag, Göttingen 2014
  K. F. Kalz
  
• New Powerful and Oxidatively Rugged Dinuclear Ru Water Oxidation Catalyst: Control of Mechanistic Pathways by Tailored Ligand Design. J. Am. Chem. Soc. 2014, 136, 24–27
  S. Neudeck, S. Maji, I. López, S. Meyer, F. Meyer, A. Llobet
  (See online at https://doi.org/10.1021/ja409974b)
• No laughing matter: the unmaking of the greenhouse gas dinitrogen monoxide by nitrous oxide reductase. Met.ions Life Sci. 2014, 14, 177-210
  L. K. Schneider, A. Wüst, A. Pomowski, L. Zhang, O. Einsle
  (See online at https://doi.org/10.1007/978-94-017-9269-1_8)
• Revisiting the Synthesis and Elucidating the Structure of Potassium Cyclopentadienyldicarbonyl-ruthenate, K[CpRu(CO)2]. Organometallics 2014, 33, 1475–1479
  K. F. Kalz, N. Kindermann, S.-Q. Xiang, A. Kronz, A. Lange, F. Meyer
  (See online at https://doi.org/10.1021/om500107j)
• Weakly Coupled Biologically Relevant Cu(II)2(μ-η1:η1-O2) cis-Peroxo Adduct that Binds Side-On to Additional Metal Ions. J. Am. Chem. Soc. 2014, 136, 7428-7434
  K.E. Dalle, T. Gruene, S. Dechert, S. Demeshko, F. Meyer
  (See online at https://doi.org/10.1021/ja5025047)
• A Computational Comparison of Oxygen Atom Transfer Catalyzed by Dimethyl Sulfoxide Reductase with Mo and W. Eur. J. Inorg. Chem. 2015, 21, 3580–3589
  J. Li, M. Andrejić, R. A. Mata, U. Ryde
  (See online at https://doi.org/10.1002/ejic.201500209)
• A Ferromagnetically Coupled (S = 1) Peroxodicopper(II) Complex. Angew. Chem. 2015, 127, 1758-1763; Angew. Chem. Int. Ed. 2015, 54, 1738-1743
  N. Kindermann, E. Bill, S. Dechert, S. Demeshko, E. J. Reijerse, F. Meyer
  (See online at https://doi.org/10.1002/anie.201409709)
• A Photocleavable Auxiliary for Extended Native Chemical Ligation. Eur. J. Org. Chem. 2015, 3095-3102
  C. Nadler, A. Nadler, C. Hansen, U. Diederichsen
  (See online at https://doi.org/10.1002/ejoc.201500033)
• A Pyrazolate-Bridged Bis(pentadentate) Ligand and Its Dinuclear Ruthenium Complex. Eur. J. Inorg. Chem. 2015, 4348–4353
  A. C. Sander, A. Schober, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1002/ejic.201500469)
• A trans-1,2 End-On Disulfide-Bridged Iron–Tetracarbene Dimer and Its Electronic Structure. Inorg. Chem. 2015, 54, 9770-9776
  S. Meyer, O. Krahe, C. Kupper, I. Klawitter, S. Demeshko, E. Bill, F. Neese, F. Meyer
  (See online at https://doi.org/10.1021/acs.inorgchem.5b01446)
• An Exclusively Organometallic {FeNO}7 Complex with Tetracarbene Ligation and a Linear FeNO Unit. Inorg. Chem. 2015, 54, 3096-3098
  C. Kupper, A. Schober, S. Demeshko, M. Bergner, F. Meyer
  (See online at https://doi.org/10.1021/acs.inorgchem.5b00301)
• Analysis of fatty acid hydroxylating cytochrome P450 enzymes, Optimus Verlag, Göttingen 2015
  V. Bruckhoff
  
• Bioinspired Organometallic Analogues of Iron-Sites in Metalloproteins, Cuvillier Verlag, Göttingen 2015
  S. Meyer
  
• Catalytic Oxidation of Alkanes and Alkenes by H2O2 with a μ-Oxido Diiron(III) Complex as Catalyst/Catalyst Precursor. Eur. J. Inorg. Chem. 2015, 3590–3601
  B. Das, A. Al-Hunaiti, M. Haukka, S. Demeshko, S. Meyer, A. A. Shteinman, F. Meyer, T. Repo, E. Nordlander
  (See online at https://doi.org/10.1002/ejic.201500576)
• Deciphering the Catalytic Mechanism of the Zn Enzyme Glutaminyl Cyclase and the Deduction of Transition-State Analog Inhibitors, Universität Göttingen, 2015
  A. Piontek
  
• Dependence of Reaction Rates for Bidirectional PCET on the Electron Donor-Electron Acceptor Distance in Phenol-[Ru(2,2'- Bipyridine)3]2+ Dyads. J. Phys. Chem. B 2015, 19, 2263-2273
  J. Chen, M. Kuss-Petermann, O. S. Wenger
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• Design, synthesis and DNA interaction of chimera between a platinum complex and an IHF mimickingpeptide. Org. Biomol. Chem. 2015, 13, 11704–11713
  H. Rao, M. S. Damian, A. Alshiekh, S. K. C. Elmroth, U. Diederichsen
  (See online at https://doi.org/10.1039/c5ob01885d)
• Development of Hybrid QM/QM Local Correlation Methods for the Study of Metal Sites in Biomolecular Catalysis, Universität Göttingen, 2015
  M. Andrejic
  
• Improved Synthesis and Detailed Characterization of a Hybrid Pyrazole-TACN Dinucleating Ligand. Z. Allg. Anorg. Chem. 2015, 641, 2181-2189
  K. E. Dalle, S. Dechert, F. Meyer
  (See online at https://doi.org/10.1002/zaac.201500563)
• Iron Complexes of a Macrocyclic N-Heterocyclic Carbene/Pyridine Hybrid Ligand. Organometallics 2015, 34, 2819–2825
  I. Klawitter, M.R. Anneser, S. Dechert, S. Meyer, S. Demeshko, S. Haslinger, A. Pöthig, F.E. Kühn, F. Meyer
  (See online at https://doi.org/10.1021/acs.organomet.5b00103)
• Metal Containing Peptides as Specific DNA Binders, Universität Göttingen, 2015
  H. Rao
  
• Modelling Binuclear Metallobiosites: Insights from Pyrazole-Supported Biomimetic and Bioinspired Complexes. Eur. J. Inorg. Chem. 2015, 3391-3405
  K. E. Dalle, F. Meyer
  (See online at https://doi.org/10.1002/ejic.201500185)
• On folding and function of natural and artificial aptamers and riboswitches, Dr. Hut Verlag, München 2015
  K. Wawrzyniak-Turek
  
• Proton-Induced, Reversible Interconversion of a μ-1,2-Peroxo and a μ-1,1-Hydroperoxo Dicopper(II) Complex. J. Am. Chem. Soc. 2015, 137, 8002-8005
  N. Kindermann, S. Dechert, S. Demeshko, F. Meyer
  (See online at https://doi.org/10.1021/jacs.5b04361)
• 1,1′-Bis(pyrazol-4-yl)ferrocenes: Potential Clip Ligands and Their Supramolecular Structures. Eur. J. Inorg. Chem.
  M. Veronelli, S, Dechert, A. Schober, S. Demeshko, F. Meyer
  (See online at https://doi.org/10.1002/ejic.201600644)
• A Structural and Functional MitoNEET Model Shows Proton Coupled Electron Transfer. J. Am. Chem. Soc.
  M. Bergner, S. Dechert, S. Demeshko, C. Kupper, J. M. Mayer, F. Meyer
  (See online at https://dx.doi.org/10.1021/jacs.6b091803)
• Complete Series of {FeNO}8, {FeNO}7, and {FeNO}6 Complexes Stabilized by a Tetracarbene Macrocycle. J. Am. Chem. Soc., 2016, 138, 7888-7898
  C. Kupper, J. A. Rees, S. Dechert, S. DeBeer, F. Meyer
  (See online at https://doi.org/10.1021/jacs.6b00584)
• Coupling of terminal iridium nitrido complexes. Inorg. Chem. Front. 2016, 3, 469–477
  J. Abbenseth, M. Finger, C. Würtele, M. Kasanmascheff, S. Schneider
  (See online at https://doi.org/10.1039/c5qi00267b)
• Crystal structure of a DNA catalyst. Nature 2016, 529, 231–234
  A. Ponce-Salvatierra, K. Wawrzyniak-Turek, U. Steuerwald, C. Höbartner, V. Pena
  (See online at https://doi.org/10.1038/nature16471)
• Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition. J. Lipid Res. 2016, 57, 276-287
  J. Newie, A. Andreou, P. Neumann, O. Einsle, I. Feussner, R. Ficner
  (See online at https://doi.org/10.1194/jlr.M064980)
• Crystal structure of alcohol oxidase from Pichia pastoris. PLoS ONE 2016, 11, e0149846
  C. Koch, P. Neumann, O. Valerius, I. Feussner, and R. Ficner
  (See online at https://doi.org/10.1371/journal.pone.0149846)
• DNA incorporation of a trans-chelating bis-pyridyl ligand for squareplanar coordinated metal cations. Inorg. Chim. Acta 2016, 452, 188-193
  F. A. Pereira, G. H. Clever
  (See online at https://doi.org/10.1016/j.ica.2016.04.024)
• Endohedral Dynamics of Push-Pull Rotorfunctionalized Cages. Chem. Commun., 2016, 52, 10411
  M. Krick, J. J. Holstein, C. Würtele, G. H. Clever
  (See online at https://doi.org/10.1039/c6cc04155h)
• Functional characterization of CYP94-genes and identification of a novel jasmonate catabolite in flowers. PLoS ONE 2016, 11, e0159875
  V. Bruckhoff, S. Haroth, K. Feussner, S. König, F. Brodhun, and I. Feussner
  (See online at https://doi.org/10.1371/journal.pone.0159875)
• Kinetics of Bis-Allylic Hydroperoxide Synthesis in the Iron-Containing Lipoxygenase 2 from Cyanothece and the Effects of Manganese Substitution. Lipids 2016, 51, 335–347
  J. Newie, M. Kasanmascheff, M. Bennati, I. Feussner
  (See online at https://doi.org/10.1007/s11745-016-4127-z)
• Light-induced Charge Separation in Densely Packed Donor- Acceptor Coordination Cages. J. Am. Chem. Soc. 2016, 138, 8279-8287
  M. Frank, J. Ahrens, I. Bejenke, M. Krick, D. Schwarzer, G. H. Clever
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• Magnetic Circular Dichroism Evidence for an Unusual Electronic Structure of a Tetracarbene−Oxoiron(IV) Complex. J. Am. Chem. Soc., 2016, 138, 14312−14325
  S. Ye, C. Kupper, S. Meyer, E. Andris, R. Navrátil, O. Krahe, B. Mondal, M. Atanasov, E. Bill, J. Roithová, F. Meyer, F. Neese
  (See online at https://doi.org/10.1021/jacs.6b07708)
• Radical transfer in E. coli ribonucleotide reductase: a NH2Y731/R411A-α mutant unmasks a new conformation of the pathway residue 731. Chem. Sci. 2016, 7, 2170–2178
  M. Kasanmascheff, W. Lee, T. U. Nick, J. Stubbe, M. Bennati
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• Reductive Transformations of a Pyrazolate-Based Bioinspired Diiron−Dinitrosyl Complex. Inorg. Chem. 2016, 55, 11538−11550
  N. Kindermann,. A. Schober, S. Demeshko, N. Lehnert, F. Meyer
  (See online at https://doi.org/10.1021/acs.inorgchem.6b02080)
• Rigid Spin Labels for Purine Nucleosides in RNA and DNA, Verlag Sierke, Göttingen, 2016
  A. Bartels
  
• Solution Chemistry of N,N’- Disubstituted Amidines: Identification of Isomers and Evidence for Linear Dimer Formation. Chem. Eur. J., 2016, 22, 18190-18196
  K. F. Kalz, A. Hausmann, S. Dechert, S. Meyer, M. John, F. Meyer
  (See online at https://doi.org/10.1002/chem.201603850)
• X-ray Absorption and Emission Spectroscopic Studies of [L2Fe2S2]n Model Complexes: Implications for the Experimental Evaluation of Redox States in Iron−Sulfur Clusters. Inorg. Chem., 2016, 55, 4485-4497
  J. K. Kowalska, A. W. Hahn, A. Albers, C. E. Schiewer, R. Bjornsson, F. A. Lima, F. Meyer, S. DeBeer
  (See online at https://doi.org/10.1021/acs.inorgchem.6b00295)