Role of thrombospondins for leukocyte trafficking to inflamed tissue (B03)

• Subject Area: Immunology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

In this project, we will elucidate the role of thrombospondins (TSPs) for myeloid leukocyte trafficking to inflamed tissue. To this end, we will first define the interactome of these matricellular proteins by mass spectrometry. Subsequently, we will employ advanced in vitro/ex vivo assays and in vivo microscopy techniques to characterize the effect of TSPs on intravascular interactions as well as on the extravascular locomotion of neutrophils and monocytes. Finally, we will use genetically altered mice to evaluate the functional relevance of TSPs for the trafficking of these immune cells in experimental sepsis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Fritz Krombach, until 6/2015; Professor Dr. Christoph Reichel