Mechanisms of cell-cell contact induced activity modulation in myeloid leukocytes (B02)

• Subject Area: Immunology
• Term: from 2011 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 165054336

The activity of immune cells is regulated by external factors derived from pathogens or tissue injury, but also by direct cell-cell contacts. Here, we will investigate how direct interactions between neutrophils and macrophages influence their mutual functional state by performing in vivo calcium imaging. Next, we will determine the role of chemokines, integrins, and calcium channels in this interplay. Finally, we will manipulate calcium levels during cell-cell contacts to analyse the importance of calcium oscillations for this process. This will give new insights into inflammatory processes and how they can be targeted.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 914: Trafficking of Immune Cells in Inflammation, Development and Disease
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Steffen Massberg; Privatdozent Dr. Konstantin Stark