EXC 1023:  ImmunoSensation: The Immune Sensory System

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2012 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194445620

• Final Report Year: 2019

Final Report Abstract

The immune system plays a central role not only in health but also in the development of many diseases. With the innovative idea of investigating the immunosensory system, which includes the immune responses of immune and non-immune cells as well their interaction with the nervous system and metabolism. ImmunoSensation has become a leading center for immunological research, especially for innate immunity. Work at the Cluster has led to new ligands and signaling molecules, a new classification for macrophages, and important contributions to the understanding of the interaction between cancer and the immune system. Our scientists have characterized the negative influence of a western diet on the immune system and discovered a new therapeutic approach to reduce age-related memory decline. Two new biotech companies began as spin-offs, and two novel compounds are in clinical trials for tumor therapy. During the first funding period of the Cluster, international research collaborations with Melbourne and Osaka were formalized, and central research topics were developed into new Collaborative Research Centers. International recruitment was extremely important to the development of the immunological focus of ImmunoSensation. Since 2012, twelve new professorships for immunological research have been established at the University of Bonn, and professorships that were vacant in the field have been restaffed with leading immunologists. Morevoer, the German Center for Neurodegenerative Diseases (DZNE) has created two professorships in neuroinflammation. Over 20% of people recruited through the Cluster came from abroad. Early-career scientists with funding from the ERC, state (NRW), or DFG (Emmy Noether Programme) were successfully recruited to Bonn. ImmunoSensation has established two new master’s programs in English (Medical Immunosciences and Infection and Immunobiology) and the International Graduate School Immunosciences and Infection, central research platforms, and a central coordination office. Additionally, the development of new research buildings (BMZ II and LIMES-TIS) and new core facilities through the acquisition of new research equipment has also contributed to the development of scientific infrastructure. Several measures for family support have been implemented, such as the creation of two new family rooms and supplementary childcare services. Young female scientists were supported through specific project funding, coaching, and networking opportunities. 50% of newly appointed professorships were filled with women, and the proportion of female project leaders increased from 19% to 32% during the first funding period. Overall, ImmunoSensation has made a lasting contribution to understanding immunosensory processes and identifying new therapeutic approaches, especially through the establishment of support programs for young scientists and gender equality. Thus, ImmunoSensation’s central goal of establishing a leading national and international scientific center for immunology was achieved.

Link to the final report

https://dx.doi.org/10.2314/KXP:1697312306

Publications

• (2012) Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation; Nature 490, 412-416
  Landsberg, J, Kohlmeyer, J, Renn, M, Bald, T, Rogava, M, Cron, M, Fatho, M, Lennerz, V, Wolfel, T, Holzel, M and Tuting, T
  (See online at https://doi.org/10.1038/nature11538)
• (2013) A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes; Nat Biotechnol 31, 76-81
  Schmid-Burgk, JL, Schmidt, T, Kaiser, V, Honing, K and Hornung, V
  (See online at https://doi.org/10.1038/nbt.2460)
• (2013) Activation and regulation of the inflammasomes; Nat Rev Immunol 13, 397-411
  Latz, E, Xiao, TS and Stutz, A
  (See online at https://doi.org/10.1038/nri3452)
• (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP; Nature 503, 530-534
  Ablasser, A, Schmid-Burgk, JL, Hemmerling, I, Horvath, GL, Schmidt, T, Latz, E and Hornung, V
  (See online at https://doi.org/10.1038/nature12640)
• (2013) cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING; Nature 498, 380-384
  Ablasser, A, Goldeck, M, Cavlar, T, Deimling, T, Witte, G, Rohl, I, Hopfner, KP, Ludwig, J and Hornung, V
  (See online at https://doi.org/10.1038/nature12306)
• (2013) Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase; Cell 153, 1094-1107
  Gao, P, Ascano, M, Wu, Y, Barchet, W, Gaffney, BL, Zillinger, T, Serganov, AA, Liu, Y, Jones, RA, Hartmann, G, Tuschl, T and Patel, DJ
  (See online at https://doi.org/10.1016/j.cell.2013.04.046)
• (2013) Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression; J Clin Invest 123, 4242-4254
  Hochheiser, K, Heuser, C, Krause, TA, Teteris, S, Ilias, A, Weisheit, C, Hoss, F, Tittel, AP, Knolle, PA, Panzer, U, Engel, DR, Tharaux, PL and Kurts, C
  (See online at https://doi.org/10.1172/JCI70143)
• (2013) iGLuc: a luciferase-based inflammasome and protease activity reporter; Nat Methods 10, 147-154
  Bartok, E, Bauernfeind, F, Khaminets, MG, Jakobs, C, Monks, B, Fitzgerald, KA, Latz, E and Hornung, V
  (See online at https://doi.org/10.1038/NMETH.2327)
• (2013) Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis; Blood 122, 1779-1788
  Peng, WM, Maintz, L, Allam, JP, Raap, U, Gutgemann, I, Kirfel, J, Wardelmann, E, Perner, S, Zhao, W, Fimmers, R, Walgenbach, K, Oldenburg, J, Schwartz, LB and Novak, N
  (See online at https://doi.org/10.1182/blood-2012-12-469882)
• (2013) Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection; Nat Immunol 14, 574-583
  Huang, LR, Wohlleber, D, Reisinger, F, Jenne, CN, Cheng, RL, Abdullah, Z, Schildberg, FA, Odenthal, M, Dienes, HP, van Rooijen, N, Schmitt, E, Garbi, N, Croft, M, Kurts, C, Kubes, P, Protzer, U, Heikenwalder, M and Knolle, PA
  (See online at https://doi.org/10.1038/ni.2573)
• (2013) Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo; Nature 498, 371-375
  Lammermann, T, Afonso, PV, Angermann, BR, Wang, JM, Kastenmuller, W, Parent, CA and Germain, RN
  (See online at https://doi.org/10.1038/nature12175)
• (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice; Nature 493, 674-678
  Heneka, MT, Kummer, MP, Stutz, A, Delekate, A, Schwartz, S, Vieira-Saecker, A, Griep, A, Axt, D, Remus, A, Tzeng, TC, Gelpi, E, Halle, A, Korte, M, Latz, E and Golenbock, DT
  (See online at https://doi.org/10.1038/nature11729)
• (2013) Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing; Immunity 39, 482-495
  Gehrke, N, Mertens, C, Zillinger, T, Wenzel, J, Bald, T, Zahn, S, Tuting, T, Hartmann, G and Barchet, W
  (See online at https://doi.org/10.1016/j.immuni.2013.08.004)
• (2013) Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?; Nat Rev Cancer 13, 365-376
  Hölzel, M, Bovier, A and Tüting, T
  (See online at https://doi.org/10.1038/nrc3498)
• (2013) RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA; J Exp Med 210, 2447-2463
  Sirois, CM, Jin, T, Miller, AL, Bertheloot, D, Nakamura, H, Horvath, GL, Mian, A, Jiang, J, Schrum, J, Bossaller, L, Pelka, K, Garbi, N, Brewah, Y, Tian, J, Chang, C, Chowdhury, PS, Sims, GP, Kolbeck, R, Coyle, AJ, Humbles, AA, Xiao, TS and Latz, E
  (See online at https://doi.org/10.1084/jem.20120201)
• (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING; EMBO J 32, 1440-1450
  Cavlar, T, Deimling, T, Ablasser, A, Hopfner, KP and Hornung, V
  (See online at https://doi.org/10.1038/emboj.2013.86)
• (2013) Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA; Cell 154, 748-762
  Gao, P, Ascano, M, Zillinger, T, Wang, W, Dai, P, Serganov, AA, Gaffney, BL, Shuman, S, Jones, RA, Deng, L, Hartmann, G, Barchet, W, Tuschl, T and Patel, DJ
  (See online at https://doi.org/10.1016/j.cell.2013.07.023)
• (2013) The immune system and kidney disease: basic concepts and clinical implications; Nat Rev Immunol 13, 738-753
  Kurts, C, Panzer, U, Anders, HJ and Rees, AJ
  (See online at https://doi.org/10.1038/nri3523)
• (2013) Turning tumors into vaccines: co-opting the innate immune system; Immunity 39, 27-37
  van den Boorn, JG and Hartmann, G
  (See online at https://doi.org/10.1016/j.immuni.2013.07.011)
• (2014) Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5’-diphosphates; Nature 514, 372-375
  Goubau, D, Schlee, M, Deddouche, S, Pruijssers, AJ, Zillinger, T, Goldeck, M, Schuberth, C, Van der Veen, AG, Fujimura, T, Rehwinkel, J, Iskarpatyoti, JA, Barchet, W, Ludwig, J, Dermody, TS, Hartmann, G and Reis e Sousa, C
  (See online at https://doi.org/10.1038/nature13590)
• (2014) Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes; Nat Commun 5, 5236
  Kim, S, Becker, J, Bechheim, M, Kaiser, V, Noursadeghi, M, Fricker, N, Beier, E, Klaschik, S, Boor, P, Hess, T, Hofmann, A, Holdenrieder, S, Wendland, JR, Frohlich, H, Hartmann, G, Nothen, MM, Muller-Myhsok, B, Putz, B, Hornung, V and Schumacher, J
  (See online at https://doi.org/10.1038/ncomms6236)
• (2014) Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium; Cell 156, 456-468
  Schiwon, M, Weisheit, C, Franken, L, Gutweiler, S, Dixit, A, Meyer-Schwesinger, C, Pohl, JM, Maurice, NJ, Thiebes, S, Lorenz, K, Quast, T, Fuhrmann, M, Baumgarten, G, Lohse, MJ, Opdenakker, G, Bernhagen, J, Bucala, R, Panzer, U, Kolanus, W, Grone, HJ, Garbi, N, Kastenmuller, W, Knolle, PA, Kurts, C and Engel, DR
  (See online at https://doi.org/10.1016/j.cell.2014.01.006)
• (2014) Cytosolic RNA:DNA hybrids activate the cGAS-STING axis; EMBO J 33, 2937-2946
  Mankan, AK, Schmidt, T, Chauhan, D, Goldeck, M, Honing, K, Gaidt, M, Kubarenko, AV, Andreeva, L, Hopfner, KP and Hornung, V
  (See online at https://doi.org/10.15252/embj.201488726)
• (2014) Dendritic cell-targeted vaccines-- hope or hype?; Nat Rev Immunol 14, 705-711
  Kastenmuller, W, Kastenmuller, K, Kurts, C and Seder, RA
  (See online at https://doi.org/10.1038/nri3727)
• (2014) Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases; Nat Commun 5, 3045
  Sommer, D, Peters, A, Wirtz, T, Mai, M, Ackermann, J, Thabet, Y, Schmidt, J, Weighardt, H, Wunderlich, FT, Degen, J, Schultze, JL and Beyer, M
  (See online at https://doi.org/10.1038/ncomms4045)
• (2014) Efficient solid-phase synthesis of pppR- NA by using product-specific labeling; Angew Chem Int Ed Engl 53, 4694-4698
  Goldeck, M, Tuschl, T, Hartmann, G and Ludwig, J
  (See online at https://doi.org/10.1002/anie.201400672)
• (2014) High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3; Nat Immunol 15, 152-160
  De Nardo, D, Labzin, LI, Kono, H, Seki, R, Schmidt, SV, Beyer, M, Xu, D, Zimmer, S, Lahrmann, C, Schildberg, FA, Vogelhuber, J, Kraut, M, Ulas, T, Kerksiek, A, Krebs, W, Bode, N, Grebe, A, Fitzgerald, ML, Hernandez, NJ, Williams, BR, Knolle, P, Kneilling, M, Rocken, M, Lutjohann, D, Wright, SD, Schultze, JL and Latz, E
  (See online at https://doi.org/10.1038/ni.2784)
• (2014) Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation; Cancer Discov 4, 674-687
  Bald, T, Landsberg, J, Lopez-Ramos, D, Renn, M, Glodde, N, Jansen, P, Gaffal, E, Steitz, J, Tolba, R, Kalinke, U, Limmer, A, Jonsson, G, Holzel, M and Tuting, T
  (See online at https://doi.org/10.1158/2159-8290.CD-13-0458)
• (2014) Innate immune activation in neurodegenerative disease; Nat Rev Immunol 14, 463-477
  Heneka, MT, Kummer, MP and Latz, E
  (See online at https://doi.org/10.1038/nri3705)
• (2014) OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids; Nat Rev Immunol 14, 521-528
  Hornung, V, Hartmann, R, Ablasser, A and Hopfner, KP
  (See online at https://doi.org/10.1038/nri3719)
• (2014) Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain; PLoS Biol 12, e1001893
  Schoofs, A, Huckesfeld, S, Schlegel, P, Miroschnikow, A, Peters, M, Zeymer, M, Spiess, R, Chiang, AS and Pankratz, MJ
  (See online at https://doi.org/10.1371/journal.pbio.1001893)
• (2014) The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation; Nat Immunol 15, 727-737
  Franklin, BS, Bossaller, L, De Nardo, D, Ratter, JM, Stutz, A, Engels, G, Brenker, C, Nordhoff, M, Mirandola, SR, Al-Amoudi, A, Mangan, MS, Zimmer, S, Monks, BG, Fricke, M, Schmidt, RE, Espevik, T, Jones, B, Jarnicki, AG, Hansbro, PM, Busto, P, Marshak-Rothstein, A, Hornemann, S, Aguzzi, A, Kastenmuller, W and Latz, E
  (See online at https://doi.org/10.1038/ni.2913)
• (2014) Transcriptome-based network analysis reveals a spectrum model of human macrophage activation; Immunity 40, 274-288
  Xue, J, Schmidt, SV, Sander, J, Draffehn, A, Krebs, W, Quester, I, De Nardo, D, Gohel, TD, Emde, M, Schmidleithner, L, Ganesan, H, Nino-Castro, A, Mallmann, MR, Labzin, L, Theis, H, Kraut, M, Beyer, M, Latz, E, Freeman, TC, Ulas, T and Schultze, JL
  (See online at https://doi.org/10.1016/j.immuni.2014.01.006)
• (2014) Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma; Nature 507, 109-113
  Bald, T, Quast, T, Landsberg, J, Rogava, M, Glodde, N, Lopez-Ramos, D, Kohlmeyer, J, Riesenberg, S, van den Boorn-Konijnenberg, D, Homig-Holzel, C, Reuten, R, Schadow, B, Weighardt, H, Wenzel, D, Helfrich, I, Schadendorf, D, Bloch, W, Bianchi, ME, Lugassy, C, Barnhill, RL, Koch, M, Fleischmann, BK, Forster, I, Kastenmuller, W, Kolanus, W, Holzel, M, Gaffal, E and Tuting, T
  (See online at https://doi.org/10.1038/nature13111)
• (2015) A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2’O-Methylated Self RNA; Immunity 43, 41-51
  Schuberth-Wagner, C, Ludwig, J, Bruder, AK, Herzner, AM, Zillinger, T, Goldeck, M, Schmidt, T, Schmid-Burgk, JL, Kerber, R, Wolter, S, Stumpel, JP, Roth, A, Bartok, E, Drosten, C, Coch, C, Hornung, V, Barchet, W, Kummerer, BM, Hartmann, G and Schlee, M
  (See online at https://doi.org/10.1016/j.immuni.2015.06.015)
• (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases; Nat Med 21, 248-255
  Coll, RC, Robertson, AA, Chae, JJ, Higgins, SC, Munoz-Planillo, R, Inserra, MC, Vetter, I, Dungan, LS, Monks, BG, Stutz, A, Croker, DE, Butler, MS, Haneklaus, M, Sutton, CE, Nunez, G, Latz, E, Kastner, DL, Mills, KH, Masters, SL, Schroder, K, Cooper, MA and O’Neill, LA
  (See online at https://doi.org/10.1038/nm.3806)
• (2015) CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model; J Clin Invest 125, 365-378
  Krauthausen, M, Kummer, MP, Zimmermann, J, Reyes-Irisarri, E, Terwel, D, Bulic, B, Heneka, MT and Muller, M
  (See online at https://doi.org/10.1172/JCI66771)
• (2015) Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial; Clin Infect Dis 61, 517-526
  Debrah, AY, Specht, S, Klarmann-Schulz, U, Batsa, L, Mand, S, Marfo-Debrekyei, Y, Fimmers, R, Dubben, B, Kwarteng, A, Osei-Atweneboana, M, Boakye, D, Ricchiuto, A, Buttner, M, Adjei, O, Mackenzie, CD and Hoerauf, A
  (See online at https://doi.org/10.1093/cid/civ363)
• (2015) Endocannabinoid signalling and the deteriorating brain; Nat Rev Neurosci 16, 30-42
  Di Marzo, V, Stella, N and Zimmer, A
  (See online at https://doi.org/10.1038/nrn3876)
• (2015) Functional classification of memory CD8(+) T cells by CX3CR1 expression; Nat Commun 6, 8306
  Bottcher, JP, Beyer, M, Meissner, F, Abdullah, Z, Sander, J, Hochst, B, Eickhoff, S, Rieckmann, JC, Russo, C, Bauer, T, Flecken, T, Giesen, D, Engel, D, Jung, S, Busch, DH, Protzer, U, Thimme, R, Mann, M, Kurts, C, Schultze, JL, Kastenmuller, W and Knolle, PA
  (See online at https://doi.org/10.1038/ncomms9306)
• (2015) Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci; Nat Commun 6, 5966
  Betz, RC, Petukhova, L, Ripke, S, Huang, H, Menelaou, A, Redler, S, Becker, T, Heilmann, S, Yamany, T, Duvic, M, Hordinsky, M, Norris, D, Price, VH, Mackay-Wiggan, J, de Jong, A, DeStefano, GM, Moebus, S, Bohm, M, Blume-Peytavi, U, Wolff, H, Lutz, G, Kruse, R, Bian, L, Amos, CI, Lee, A, Gregersen, PK, Blaumeiser, B, Altshuler, D, Clynes, R, de Bakker, PIW, Noethen, MM, Daly, MJ and Christiano, AM
  (See online at https://doi.org/10.1038/ncomms6966)
• (2015) Innate immunity in Alzheimer’s disease; Nat Immunol 16, 229-236
  Heneka, MT, Golenbock, DT and Latz, E
  (See online at https://doi.org/10.1038/ni.3102)
• (2015) MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment; Nat Commun 6, 8755
  Riesenberg, S, Groetchen, A, Siddaway, R, Bald, T, Reinhardt, J, Smorra, D, Kohlmeyer, J, Renn, M, Phung, B, Aymans, P, Schmidt, T, Hornung, V, Davidson, I, Goding, CR, Jonsson, G, Landsberg, J, Tuting, T and Holzel, M
  (See online at https://doi.org/10.1038/ncomms9755)
• (2015) Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions; Cell 162, 1322-1337
  Eickhoff, S, Brewitz, A, Gerner, MY, Klauschen, F, Komander, K, Hemmi, H, Garbi, N, Kaisho, T, Germain, RN and Kastenmuller, W
  (See online at https://doi.org/10.1016/j.cell.2015.08.004)
• (2015) Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA; Nat Immunol 16, 1025-1033
  Herzner, AM, Hagmann, CA, Goldeck, M, Wolter, S, Kubler, K, Wittmann, S, Gramberg, T, Andreeva, L, Hopfner, KP, Mertens, C, Zillinger, T, Jin, T, Xiao, TS, Bartok, E, Coch, C, Ackermann, D, Hornung, V, Ludwig, J, Barchet, W, Hartmann, G and Schlee, M
  (See online at https://doi.org/10.1038/ni.3267)
• (2015) The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation; Nat Commun 6, 7088
  Kuhn, S, Erdmann, C, Kage, F, Block, J, Schwenkmezger, L, Steffen, A, Rottner, K and Geyer, M
  (See online at https://doi.org/10.1038/ncomms8088)
• (2015) The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells; Immunity 42, 850-863
  Zehner, M, Marschall, AL, Bos, E, Schloetel, JG, Kreer, C, Fehrenschild, D, Limmer, A, Ossendorp, F, Lang, T, Koster, AJ, Dubel, S and Burgdorf, S
  (See online at https://doi.org/10.1016/j.immuni.2015.04.008)
• (2016) Alzheimer’s disease risk variants modulate endophenotypes in mild cognitive impairment; Alzheimers Dement 12, 872-881
  Louwersheimer, E, Wolfsgruber, S, Espinosa, A, Lacour, A, Heilmann-Heimbach, S, Alegret, M, Hernandez, I, Rosende-Roca, M, Tarraga, L, Boada, M, Kornhuber, J, Peters, O, Frolich, L, Hull, M, Ruther, E, Wiltfang, J, Scherer, M, Riedel-Heller, S, Jessen, F, Nothen, MM, Maier, W, Koene, T, Scheltens, P, Holstege, H, Wagner, M, Ruiz, A, van der Flier, WM, Becker, T and Ramirez, A
  (See online at https://doi.org/10.1016/j.jalz.2016.01.006)
• (2016) An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice; Kidney Int 90, 525-539
  Ludwig-Portugall, I, Bartok, E, Dhana, E, Evers, BD, Primiano, MJ, Hall, JP, Franklin, BS, Knolle, PA, Hornung, V, Hartmann, G, Boor, P, Latz, E and Kurts, C
  (See online at https://doi.org/10.1016/j.kint.2016.03.035)
• (2016) Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels; Biol Psychiatry 79, 858-868
  Jenniches, I, Ternes, S, Albayram, O, Otte, DM, Bach, K, Bindila, L, Michel, K, Lutz, B, Bilkei-Gorzo, A and Zimmer, A
  (See online at https://doi.org/10.1016/j.biopsych.2015.03.033)
• (2016) Atopic dermatitis; Lancet 387, 1109-1122
  Weidinger, S and Novak, N
  (See online at https://doi.org/10.1016/S0140-6736(15)00149-X)
• (2016) Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain; Nat Commun 7, 12796
  Huckesfeld, S, Peters, M and Pankratz, MJ
  (See online at https://doi.org/10.1038/ncomms12796)
• (2016) CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism; Nat Commun 7, 12338
  chmid-Burgk, JL, Honing, K, Ebert, TS and Hornung, V
  (See online at https://doi.org/10.1038/ncomms12338)
• (2016) Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection; J Exp Med 213, 1409-1418
  Wilhelm, C, Harrison, OJ, Schmitt, V, Pelletier, M, Spencer, SP, Urban, JF, Jr., Ploch, M, Ramalingam, TR, Siegel, RM and Belkaid, Y
  (See online at https://doi.org/10.1084/jem.20151448)
• (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming; Sci Transl Med 8, 333ra350
  Zimmer, S, Grebe, A, Bakke, SS, Bode, N, Halvorsen, B, Ulas, T, Skjelland, M, De Nardo, D, Labzin, LI, Kerksiek, A, Hempel, C, Heneka, MT, Hawxhurst, V, Fitzgerald, ML, Trebicka, J, Bjorkhem, I, Gustafsson, JA, Westerterp, M, Tall, AR, Wright, SD, Espevik, T, Schultze, JL, Nickenig, G, Lutjohann, D and Latz, E
  (See online at https://doi.org/10.1126/scitranslmed.aad6100)
• (2016) Discriminating self from non-self in nucleic acid sensing; Nat Rev Immunol 16, 566-580
  Schlee, M and Hartmann, G
  (See online at https://doi.org/10.1038/nri.2016.78)
• (2016) Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment; Sci Immunol 1, eaai7677
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