The molecular basis of the diversity and functional specificity of neuronal metabotropic glutamate receptor-mediated signaling (P20)

• Subject Area: Biochemistry
• Term: from 2011 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

Metabotropic glutamate receptors (mGluRs) are key modulators of excitatory synaptic transmission in the nervous system and act on a number of effectors and signalling pathways. However, the mechanisms behind their functional specificity have so far remained largely unclear. Using a comprehensive functional proteomic approach we identified a distinct set of mGluR interaction partners that include effectors as well as determinants for localization at specific membrane domains. We will now investigate these proteins further with respect to their role for mGluR architecture, signalling domain formation and functional specificity in neurons.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Dr. Uwe Schulte