Transcription in E. coli: Structural Basis of Nus-Factor Dependent Regulation

• Applicant: Professor Dr. Paul Rösch
• Subject Area: Structural Biology
• Term: from 2011 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192440363

• Final Report Year: 2015

Final Report Abstract

No abstract available

Publications

• Domain interactions of the transcription-translation coupling factor Escherichia coli NusG are intermolecular and transient. Biochem J. 2011 435:783-9
  Burmann BM, Scheckenhofer U, Schweimer K, Rösch P
  
• NusA interaction with the α subunit of E. coli RNA polymerase is via the UP element site and releases autoinhibition. Structure. 2011 19:945-54
  Schweimer K, Prasch S, Sujatha PS, Bubunenko M, Gottesman ME, Rösch P
  
• The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling: from structure to mechanism. Transcription. 2011 2:130-4
  Burmann BM, Rösch P
  
• An α-helix to β-barrel domain switch transforms the transcription factor RfaH into a translation factor. Cell. 2012 150:291-303
  Burmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, Rösch P
  (See online at https://doi.org/10.1016/j.cell.2012.05.042)
• Fast mapping of biomolecular interfaces by Random Spin Labeling (RSL). J Biomol Struct Dyn. 2012 29:793-8
  Hartl MJ, Burmann BM, Prasch SJ, Schwarzinger C, Schweimer K, Wöhrl BM, Rösch P, Schwarzinger S
  (See online at https://doi.org/10.1080/073911012010525021)
• Transformation: the next level of regulation. RNA Biol. 2012A 9:1418-23
  Knauer SH, Rösch P, Artsimovitch I
  (See online at https://doi.org/10.4161/rna.22724)
• Transformer proteins. Cell Cycle. 2012B 11:4289- 90
  Knauer SH, Artsimovitch I, Rösch P
  
• An autoinhibited state in the structure of Thermotoga maritima NusG. Structure. 2013 21:365-75
  Drögemüller J, Stegmann CM, Mandal A, Steiner T, Burmann BM, Gottesman ME, Wöhrl BM, Rösch P, Wahl MC, Schweimer K
  (See online at https://doi.org/10.1016/j.str.2012.12.015)
• Transformers - the science, not the fiction. QUIPS article of the Protein Data Bank in Europe. 2013 06/2013
  Knauer SH
  
• Interdomain contacts control folding of transcription factor RfaH. Nucleic Acids Res. 2014 41:10077-85
  Tomar S, Knauer S, Rösch P, Artsimovitch I
  (See online at https://doi.org/10.1093/nar/gkt779)
• Determination of RNA polymerase binding surfaces o transcription factors by NMR spectroscopy. Scientific Reports volume 5, Article number: 16428 (2015)
  Strauß M, Drögemüller J, Schweimer K, Jurk M, Knauer SH, Rösch P
  (See online at https://doi.org/10.1038/srep16428)
• Exploring RNA Polymerase Regulation by NMR Spectroscopy, Sci Rep. Scientific Reports volume 5, Article number: 10825 (2015)
  Drögemüller J, Strauß M, Schweimer K, Wöhrl BM, Knauer SH, Rösch P
  (See online at https://doi.org/10.1038/srep10825)
• The two domains of Mycobacterium tuberculosis NusG protein are dynamically independent. J Biomol Dyn. Journal of Biomolecular Structure and Dynamics, 34:2, 352-361, 2016
  Strauß M, Schweimer K, Burmann BM, Richter A, Güttler A, Wöhrl BM, Rösch P
  (See online at https://doi.org/10.1080/07391102.2015.1031700)