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Motor pattern selection - sensory and neuromodulatory influences

Applicant Professor Dr. Harald Wolf, since 2/2012
Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Term from 2011 to 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 191323453
 
Final Report Year 2016

Final Report Abstract

Handling an overwhelming amount of sensory input and responding adequately to the situation at hand is the most fascinating ability of the nervous system, because it serves to adapt the animal's behavior to the changing requirements of the body and the environment. The flexibility of motor responses often results from a dynamic adaptation of existing motor networks via the actions of neuromodulators that are released from descending pathways originating in higher centers of the nervous system. This project investigates the contribution of descending modulatory neurons to sensorimotor processing, the subsequent selection of adequate motor responses, and the stability of the generated behavior. For this, we are studying the interactions between sensory and modulatory neurons and the representation of proprioceptive and exteroceptive sensory information within the population of modulatory neurons. We are using the well-characterized pattern-generating networks of the stomatogastric nervous system of the crab for our experiments. Sensory, modulatory and motor neurons are available in manageable numbers in this system and intrinsic and synaptic properties have been identified. We find that descending modulation affects the earliest stage of information processing in the nervous system: Action potential initiation and thus information encoding in sensory axons is dependent on modulatory influences, allowing the central nervous system to modulate its own input, making this input task- and state-dependent. On the motor side, neuromodulators elicit distinct behaviors from multifunctional motor circuits. Once these behaviors are active, we find that with in vivo modulatory conditions, behaviors are stabilized by the actions of neuromodulators. Finally, together with our collaborators, we have provided the first de-novo genome sequence of a decapod crustacean. We are currently establishing marbled crayfish as a new genetic model organism. Our data demonstrate that all animals of this parthenogenetic species are clones and genetically identical. We have annotated first neuronal genes of interest and generated primers to quantify modulator actions in identified neurons.

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