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Charakterisierung und funktionelle Analyse der Interaktion zwischen Polo-like Kinase 1 und mitotischem Zentromer-assoziierten Kinesin

Subject Area Gynaecology and Obstetrics
Term from 2011 to 2015
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 188052775
 
Final Report Year 2015

Final Report Abstract

In summary, our observations have greatly contributed to the molecular mechanism by which the mitotic kinase Plk1 regulates MCAK. Overexpression of Plk1, observed in various human tumors, contributes greatly to the deregulated MCAK, leading further to genome instability and abnormal microtubule dynamics, which could subsequently modulate the cytoskeleton and mobility, and promote invasion, metastasis and therapy resistance of tumor cells. Further investigations are currently ongoing to address these issues.

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