The cell membrane as regulatory element of transmembrane protease function (A04)

• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440785

The project deals with the physiologic activation mechanisms of ADAM10 and ADAM17. Transient breakdown of phospholipid asymmetry of the cellular membrane was identified as a decisive event in ADAM17 activation. Mice with a deletion of the putative phosphatidylserine-binding motif in ADAM17 were generated and will be characterized. Furthermore, a role of scramblases in ADAM17 activation will be analyzed to address whether phosphatidylserine-exposure represents a general mechanism in the control of membrane-anchored sheddases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 877: Proteolysis as a Regulatory Event in Pathophysiology
• Applicant Institution: Christian-Albrechts-Universität zu Kiel
• Project Head: Professorin Dr. Karina Reiss