Project Details
Projekt
True Moving Bed Centrifugal Partition Chromatography Unit
Subject Area
Process Engineering, Technical Chemistry
Term
Funded in 2010
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 175803131
The overall objective of this application is to establish a general approach (rules) for liquid-liquid chromatography separation process development at technical scale (TMB Centrifugal Partition Chromatograph (TMB CPC)), for both batch and continuous separations. We want to develop an approach applicable to a wide range of specific bioproducts separation and purification problems. The method should guide the user in the selection of the mobile and stationary phases (both liquid in liquid-liquid chromatography), operating mode and operating conditions, in order to achieve separation requirements in terms of product purity, recovery and productivity. The input information of the considered approach is: physico-chemical properties of the target component and adjacent impurities, separation purpose (mixture fractionation, target component capturing or polishing) and required separation performances (purity, yield, productivity). All parameters affecting the chromatographic separation efficiency (thermodynamics, hydrodynamics and mass transfer parameters) as well as possible operating modes will be studied systematically through research tasks organized in 5 projects, whose realization is planned in the next 9 years. The aim is to develop a mathematical model based separation process design procedure and minimize the experimental effort for the determination of the parameters governing the process. So, this hardware is crucial for our success.
DFG Programme
Major Research Instrumentation
Instrumentation Group
1350 Flüssigkeits-Chromatographen (außer Aminosäureanalysatoren 317), Ionenaustauscher
Applicant Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
