Dynamics of the fungal COP9 signalosome and LID MPN/PCI complexes (B06)

• Subject Area: Biochemistry
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105286809

Our focus in the next funding period will be the sequential order of the assembly of the fungal COP9 signalosome (CSN) in vivo from a trimeric and heptameric pre-CSN to a functional CSN. Posttranslational modifications in the assembly of CSN and of the lid of the 19S regulatory particle of the proteasome will be compared. Dynamics of CSN and lid supercomplexes with SemA, the fungal CandA complex of A. nidulans or E3 SCF ubiquitin ligases be addressed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 860: Integrative Structural Biology of Dynamic Macromolecular Assemblies
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Gerhard H. Braus