Functional characterization of the balance between the major cytoplasmic poly(A) polymerase GLD-2 and deadenylases in C. elegans germ cells.

• Applicant: Professor Dr. Christian R. Eckmann
• Subject Area: Developmental Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 169324141

• Final Report Year: 2021

Final Report Abstract

No abstract available

Publications

• Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc Natl Acad Sci USA 112, 8614–8619 (2015)
  Nakel, K., Bonneau, F., Eckmann, C. R. and Conti, E.
  (See online at https://doi.org/10.1073/pnas.1504648112)
• Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Cell 166, 1572–1584.e16 (2016)
  Saha, S., Weber, C.A., Nousch, M., Adame-Arana, O., Hoege, C., Hein, M.Y., Osborne Nishimura, E., Mahamid, J., Jahnel, M., Jawerth, L., Pozniakovski, A., Eckmann, C. R., Jülicher, F. and Hyman, A.A.
  (See online at https://doi.org/10.1016/j.cell.2016.08.006)
• Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)- polymerase activity. RNA 22, 1139–1145 (2016)
  Nakel, K. Bonneau, F., Basquin, C., Habermann, B., Eckmann, C. R. and Conti, E.
  (See online at https://doi.org/10.1261/rna.056598.116)
• Polyadenylation is the key aspect of GLD-2 function in C. elegans. RNA 23, 1180–1187 (2017)
  Nousch, M., Minasaki, R. and Eckmann, C. R.
  (See online at https://doi.org/10.1261/rna.061473.117)
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, M., Yeroslaviz, A. and Eckmann, C. R.
  (See online at https://doi.org/10.1093/nar/gkz787)
• Stage-specific combinations of opposing poly(A) modifying enzymes guide gene expression during early oogenesis. Nucleic Acids Res 47, 10881–10893 (2019)
  Nousch, M., Yeroslaviz, A. and Eckmann, C. R.
  (See online at https://doi.org/10.1093/nar/gkz787)