Ultra-hoch-auflösendes ESI LCMS/MS Q-TOF Massenspektrometer
Final Report Abstract
The combination of maXis ESI-TOF mass spectrometer with LCMS and in particularly with the cryo-spray was proven to be extremely valuable for achieving new and breakthrough results in our projects and collaborations in the multidisciplinary fields of biomedical relevance and catalysis, such as: bioinorganic chemistry, especially chemistry of redox signaling, medicinal chemistry of metal based drugs and structure-based ligand discovery, physiology of neuro signaling, supramolecular chemistry, chemistry of polyoxometalates, chemical- and photo-catalyses. The applied instrumentation method was indispensible for characterization of highly unstable or reactive intermediate species (e.g. a new signaling molecule HSNO, nonheme iron(III)-peroxo, manganese(II)- hydroxo, dicopper peroxo, encapsulated metalloporphyrins etc.) and elucidation of reaction pathways involved in versatile type of stoichiometric or catalytic reactions. The obtained results have been important for launching Emerging Field Initiative of “Medicinal redox Inorganic Chemistry”, as well as for our participation in the research network "Solar Technologies Go Hybrid". At the same time the powerful cryospray mass spectrometric technique that we can performed by using this instrumentation set-up enabled us to established a number of fruitful national and international cooperations, which demonstrates that there is a great demand for the application of this technique in the wide range of scientific disciplines.
Publications
- Novel dinuclear platinum(II) complexes containing mixed nitrogen-sulfur donor ligands. Inorganic Chemistry, Vol. 50. 2011, Issue 24, pp. 12747–12761.
Hochreuther, S.; Puchta, R.; van Eldik, R.
(See online at https://dx.doi.org/10.1021/ic2018902) - Solution and solid-state interactions in a supramolecular ruthenium photosensitizerpolyoxometalate Aggregate. Chemical Communications, Vol. 47. 2011, pp. 6852-6854.
Heussner, K.; Peuntinger, K.; Rockstroh, N.; Nye, L. C.; Ivanović- Burmazović, I.; Rau, S.; Streb, C.
(See online at https://dx.doi.org/10.1039/C1CC11859E) - Water Exchange Reactivity and Stability of Cobalt Polyoxometalates under Catalytically Relevant pH Conditions: Insight into Water Oxidation Catalysis. Inorganic Chemistry, Vol. 50. 2011, Issue 18, pp. 9053–9058.
Lieb, D.; Zahl, A.; Wilson, E. F.; Streb, C.; Nye, L. C.; Meyer, K.; Ivanović-Burmazović, I.
(See online at https://dx.doi.org/10.1021/ic201243n) - Chemical and Photochemical Functionality of the First Molecular
Bismuth Vanadium Oxide. Chemistry - A European Journal, Vol. 18. 2012, Issue 35, pp. 10949–10953.
Tucher, J.; Nye, L.C.; Ivanovic-Burmazovic, I.; Notarnicola, A.; Streb, C.
(See online at https://dx.doi.org/10.1002/chem.201200404) - Chemical Characterization of the Smallest S-nitrosothiol, HSNO;
Cellular Cross-talk of H2S and S-nitrosothiols. Journal of the American Chemical Society, Vol. 134. 2012, Issue 9, pp. 12016–12027.
Filipović, M.R.; Miljković, J.; Nauser, T.; Royzen, M.; Klos, K.; Shubina, T.E.; Koppenol, W.H.; Lippard, S J.; Ivanovic-Burmazović; I.
(See online at https://dx.doi.org/10.1021/ja3009693) - Metal substitution in a Lindqvist polyoxometalate leads to improved photocatalytic performance. Dalton Transactions, Vol. 41. 2012, pp. 9938-9943.
Tucher, J.; Wu, Y.; Nye, L.C.; Ivanovic-Burmazovic, I.; Khusniyarov, M. M.; Streb, C.
(See online at https://dx.doi.org/10.1039/C2DT30304C) - A mononuclear nonheme iron(III)-peroxo complex binding redox-inactive metal Ions. Chemical Science, Vol. 4. 2013, pp. 3917-3923.
Lee, Y.M.; Bang, S.; Kim, Y.M.; Cho, J.; Hong, S.; Nomura, T.; Ogura, T.; Troeppner, O.; Ivanović-Burmazović, I.; Sarangi, R.; Fukuzumi, S.; Nam, W.
(See online at https://dx.doi.org/10.1039/C3SC51864G) - Beyond H2S and NO interplay: hydrogen sulfide and nitroprusside react directly to give nitroxyl (HNO). A new pharmacological source of HNO. Journal of Medicinal Chemistry, Vol. 56. 2013, Issue 4, pp. 1499–1508.
Filipovic, M. R.; Eberhardt, M.; Prokopovic, V.; Mijuskovic, A.; Orescanin-Dusic, Z.; Reeh, P.; Ivanović-Burmazović. I.
(See online at https://dx.doi.org/10.1021/jm3012036) - Dinuclear Seven-Coordinate Mn2+ Complexes. Effect of Manganese(II)-Hydroxo Species on Water Exchange and Superoxide Dismutase Activity.
Inorganic Chemistry, Vol. 52. 2013, Issue 1, pp. 222–236.
Lieb, D.; Friedel, F.; Mirza, Y.; Zahl, A.; Khusniyarov, M.; Heinemann, F.; Ivanovic-Burmazovic, I.
(See online at https://dx.doi.org/10.1021/ic301714d) - Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery. Molecular Pharmacology, Vol. 84. 2013, Issue 4, pp. 528-540.
Kruse, A.C.; Weiss, D.R.; Rossi, M.; Hu, J.; Hu, K.; Eitel, K.; Gmeiner, P.; Wess, J.; Koblika, B.K.; Shoichet, B.K.
(See online at https://doi.org/10.1124/mol.113.087551)
