Control of tumor cell proliferation, migration and invasion by SNAIL1-induced changes in Wnt and BMP pathway activity (B05)

• Subject Area: Cell Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

The project pursues the working-hypothesis that SNAIL1 hijacks Wnt and BMP signaling to stimulate EMT-associated gene expression in colorectal cancer, and will dissect the role of LEF1, a Wnt pathway effector, and of SMAD proteins, mediators of BMP signals, in the execution of EMT. Novel LEF1- and BMP-regulated genes will be identified and their impact on proliferation and invasion will be characterized.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Andreas Hecht