Understanding the role of the BRAFV600E oncoprotein in colorectal cancer initiation and metastasis (B04)

• Subject Area: Cell Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

This project aims to decipher the mechanisms by which the highly aggressive BRAFV600E mutant colon cancer – often associated with peritoneal carcinomatosis – establishes its characteristic metastatic spreading pattern. B4 will characterize BRAFV600E target genes and address how BRAFV600E cooperates with other signaling pathways. In collaboration with C11 (N) this project will identify factors that mediate homing to the peritoneum.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Tilman Brummer