Advanced imaging of dynamic ECM – cell interactions using genetically encoded live-reporters during cell migration in development and in adult tissues (A03)

• Subject Area: Developmental Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

Novel extracellular matrix (ECM) reporter alleles in mouse were developed that allow for visualization of cell – ECM interactions. These are used to study basement membrane invasion during EMT at gastrulation and for functional studies of cell – ECM interactions for the mesenchymal and amoeboid migration of macrophages within their native, adult tissue environments using advanced in vivo live microscopy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Sebastian J. Arnold; Professor Dr. Tim Lämmermann, Ph.D.