CTLA-4 (CD152)-induced signaling pathways as regulators of CD8+ T lymphocytes (B14)

• Subject Area: Immunology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

To prevent immunopathology, differentiation of CD8+ T cells is tightly controlled by inhibitory receptors such as CTLA-4. Project B14, in collaboration with B16, identified by iTRAQ mass spectrometry novel signal transduction pathways downstream of CTLA-4 that will be further characterized in the 3rd funding period. In this respect, B14 will connect changes in cellular metabolism with altered T cell functions. The role of CTLA-4-mediated TCF-1 regulation in memory formation will be analyzed in a Listeria infection model in collaboration with A05. Furthermore, B14 will analyze the impact of CTLA-4 on JAML in the context of co-stimulation and adhesion in collaboration with B08 and B12.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Head: Professorin Dr. Monika Christine Brunner-Weinzierl