Role of the synaptic cell adhesion molecule Neuroplastin in the immune system: relevance for signaling and Ca2+ homeostasis during T cell development and activation (B08)

• Subject Area: Immunology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 97850925

This project will use conventional and inducible KO mice for Neuroplastin and plasma membrane Ca2+ ATPases to characterize the impact of disturbed Ca2+ clearance on T cell signaling and assess possible Ca2+-independent roles of Neuroplastin (collaborations with A04, A29N, B19 and Z01). Supported by projects B14 and A25, Nptn -/- T cells will be challenged in in vivo models for selected aspects of immune activation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 854: Molecular Organisation of Cellular Communications within the Immune System
• Applicant Institution: Otto-von-Guericke-Universität Magdeburg
• Project Heads: Professor Dr. Eckart D. Gundelfinger; Dr. Ulrich Thomas