Specific interactions of lipids with protein transmembrane segments (01)

• Subject Area: Cell Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 112927078

Membrane lipids not only serve as structural components of membranes but are also important modulators of protein function. Based on our observation of a specific protein-sphingolipid interaction, which modulates the protein’s activity, we will continue to identify and characterize non-covalent interactions of lipids with membrane proteins. In addition, we will focus on cholesteroylated proteins as covalent protein-lipid interactions. We will study molecular mechanisms and functions of this rare type or protein lipidation. Both projects are supported by mass spectrometric analyses of lipids, and we will continue our work towards the comprehensive analysis of lipids from biological sources.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 83: Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professorin Dr. Britta Brügger; Professor Dr. Felix Wilhelm Theodor Wieland, until 12/2017