Cooperative Effects in Metal-Modified DNA (B09)

• Subject Area: Inorganic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 104405829

The project investigates various cooperative effects related to metal-modified DNA. In particular, the formation of polynuclear metal-mediated base pairs will be studied, as this may principally proceed in a cooperative, non-cooperative or anti-cooperative manner. Moreover, metal-mediated base pairs involving ambident ligands will be investigated to verify their preferred coordination geometry and to determine how their formation influences the cooperativity of the DNA melting process. Finally, planar metal complexes will be developed that selectively recognize guanine quadruplex structures. Here, the cooperativity of the ligands in determining the quadruplex affinity and selectivity of the respective complex will be evaluated.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 858: Synergetic Effects in Chemistry - From Additivity towards Cooperativity
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Jens Müller