Immune responses to native and artificial extracellular matrices (B03)

• Subject Area: Dermatology
• Term: from 2009 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 59307082

J. Simon and S. Franz have identified important mechanisms of immune modulation by GAG derivatives. Their aim in the third funding period is to investigate multifunctional hydrogels adapted to the different phases of wound healing (e.g. combination of anti-inflammatory and regeneration-promoting functions). It also planned to evaluate how sHA-based hydrogels terminate inflammation in chronic wounds. In a translational approach, the immunomodulatory effects of aECM will be validated using wound fluids and macrophages from patients suffering from impaired wound healing.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone und Skin - From Material Science to Clinical Application
• Applicant Institution: Universität Leipzig
• Project Heads: Professorin Dr. Sandra Franz; Professor Dr. Jan-Christoph Simon