Chemical modification of proteins for the characterization of matrix-protein interactions (A04)

• Subject Area: Public Health, Healthcare Research, Social and Occupational Medicine ; Biochemistry
• Term: from 2009 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 59307082

The aim of A. Beck-Sickinger is to improve the biocompatible properties of implants by specific coatings. For this purpose, multifunctional peptides are synthesized that bind to surfaces and carry mediators to improve wound healing. The peptides are structured via biocompatible bioorganic modification with segments of the ECM and specifically releasable proteins (e.g., CXCL12, chemerin, FGF2, VEGF) to increase the biocompatibility of the implants.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 67: Functional Biomaterials for Controlling Healing Processes in Bone und Skin - From Material Science to Clinical Application
• Applicant Institution: Universität Leipzig
• Project Head: Professorin Dr. Annette G. Beck-Sickinger