Project Details
Projekt
Regulation of nuclear egress of human cytomegalovirus through a multifunctional viral-cellular protein complex (C03)
Subject Area
Virology
Term
from 2009 to 2017
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 52732026
The C3 work program addresses four topics: (i) the mechanistic characterization of HCMV-specific core NEC heterodimerization, (ii) the question of conservation of this essential NEC scaffolding principle among herpesviruses, (iii) a detailed analysis of the various regulatory functions recruited to the multimeric NEC and, (iv) an exploitation of the NEC as a putative cross-spanning antiherpesviral drug target. Thus, our project will provide new information on the NEC-specific structure-function relationship focusing on its multifaceted mode of virus-host interaction.
DFG Programme
Collaborative Research Centres
Applicant Institution
Friedrich-Alexander-Universität Erlangen-Nürnberg
Project Head
Professor Dr. Manfred Marschall
