Hedgehog-Gli signalling in skin homeostasis and tumour formation (A03)

• Subject Area: Dermatology ; Cell Biology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 73111208

Indian Hedgehog (Ihh) controls proliferation and differentiation of keratinocytes and prevents tumour progression and metastasis. Mechanistically, complex epidermal hedgehog function is mediated by the interplay of Gli2 and Gli3 transcription factors. This project uses Hedgehog signalling as paradigm to address the fundamental question how canonical signalling pathways can on one hand induce an uniform cell response and on the other hand excite a variety of different and cell type-specific activities to both, maintain tissue homeostasis and contribute to disease formation.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 829: Molecular Mechanisms Regulating Skin Homeostasis
• Applicant Institution: Universität zu Köln
• Project Head: Privatdozentin Dr. Catherin Niemann