The role of proteins on fusion and fission: computer simulation of coarse-grained models (B03)

• Subject Area: Biophysics
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 55908123

The aim of the project consists in investigating the mechanism, the structure and thermodynamics of transition states in protein-mediated collective processes that alter the membrane topology. Within the framework of coarse-grained models of lipids and proteins, we will employ advanced free-energy techniques and devise continuum models to study how pathways and rates depend on membrane tension and geometry as well as on the molecular architecture of lipids and proteins in order to identify conditions that facilitate fusion or fission.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 803: Functionality Controlled by Organisation in and between Membranes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Marcus Müller