Crosstalk between matrix and ROS signaling during renal inflammation and fibrosis (A05)

• Subject Area: Pharmacology ; Nephrology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

In the last funding period we have demonstrated that soluble biglycan, an endogenous ligand of the innate immune receptors TLR2/4, evokes albuminuria in a ROS-dependent mannner and modulates the progression of inflammatory renal diseases via NOX2. Our main goal is to decipher the cellular mechanism of biglycan-mediated modulation of the redox-homeostasis for the development of novel anti-proteinuric and anti-inflammatory therapies. Accordingly, in this project we will identify the source and determine the impact of ROS on biglycan-induced albuminuria, and will mechanistically investigate biglycan-dependent stabilization of NOX2 for the inhibition of IL-1 synthesis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Head: Professorin Dr. Liliana Schaefer