Nox4 as a redox switch in epigenetics and metabolism (A01)

• Subject Area: Anatomy and Physiology
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463

The NADPH oxidase Nox4 mediates cellular differentiation, maintains endothelial quiescence and regulates angiogenesis by controlling the expression of Hif1α. In the new funding period we will focus on the following key aspects: 1. Identification the role of Nox4 in differentiation from iPSCs into endothelial cells. 2. Identification of Nox4s role in Hif1α expression and 3. Analysis of the role of Nox4 in metabolomics control.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 815: Redox-Regulation: Generating Systems and Functional Consequences
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Ralf P. Brandes; Professorin Dr. Katrin Schröder, Ph.D.