Statistical methods for time-varying electrophysiological data and for protein-membrane interactions (Z02)

• Subject Area: Biophysics
• Term: from 2009 to 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 55908123

We will develop statistical methods to model and evaluate electrophysiological data including ion channel recordings with time-varying membrane potential or tension. We further aim to get precise insight into the resolution limit for estimating event times. Extending previous work on the effective dimensionality reduction of the configurational dynamics of membrane protein complexes, we will study the relation between collective protein dynamics and the dynamics of different individual lipids, which requires extension of partial least squares methodology to multi-dimensional time series.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 803: Functionality Controlled by Organisation in and between Membranes
• Applicant Institution: Georg-August-Universität Göttingen
• Project Head: Professor Dr. Axel Munk