GRK 1591:  Posttranscriptional Control of Gene Expression: Mechanisms and Role in Pathogenesis

• Subject Area: Basic Research in Biology and Medicine
• Term: from 2010 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 105533105

• Final Report Year: 2019

Final Report Abstract

The RTG1591 „Post-transcriptional control of gene expression: mechanisms and role in pathogenesis” was established at the Martin Luther University Halle-Wittenberg (MLU) in 2010. Its main goal was the structured training of PhD and MD students in investigating how deregulation of gene expression at the level of (m)RNA modulates diseases in humans and plants. To this end, the RTG1591 combined interdisciplinary research efforts of scientists from respective fields who aimed at investigating molecular mechanisms underlying the post-transcriptional control of gene expression (PTCG), the role of deregulated PTCG in human diseases encompassing cardiovascular diseases as well as cancer, and the deregulated PTCG in plants and plant-pathogen interactions. These efforts allowed establishing a truly interdisciplinary training framework for natural science as well as medical students. The major goal of the training network was to educate students in high-end technologies, theoretical as well as professional skills to pursue an independent career in academia or industry. The scientific goal of the RTG1591 was to promote our understanding of disease-relevant mechanisms underlying the RNA-dependent control of gene expression. This research focus was motivated by the substantial progress in this research field since the beginning of this millennium when the impact and ample applications of small interfering RNAs (siRNAs), microRNAs, sRNAs (small bacterial RNAs) and RNA-binding proteins (RBPs) modulating their mode of action was begun to be unraveled. Although the medical and agricultural application of the since then gained knowledge is still in its infancy, the recent approval of the first RNA-based medication like nusinersen and patisiran emphasizes the hyperopia of establishing a structured training program for early career scientists to fuel the progress of the involved research efforts. The RTG1591 directly supported and trained 45 natural scientist PhD and 16 medical students since 2010. The vast majority of these successfully pursued an academic career in the RNA field or in pharmaceutic industry. The scientific output of the RTG1591 was substantial with 46 peer-reviewed scientific articles published since 2010 with participation of students directly supported by the RTG1591 and a total of 102 publications of RTG1591-associated publications. Moreover, the design and leitmotiv of the RTG1591’s training program inspired the establishment of two other research training groups at the MLU, the RTG2155 and the RTG2467. These evolved and adapted the training concepts of the RTG1591 to fit their field of research interest. Most importantly, however, the major progress in addressing the role of RNA/RBP-guided regulation of gene expression (R3oGE) in human diseases inspired by the RTG1591 set the stage for a collaborative research center initiative (CRC1440) entitled “RNA in focus (RIF) – From mechanisms to novel therapeutic strategies in human medicine”. The CRC1440 aims at continuing the research efforts of the RTG1591 at a scientifically evolved level to pursue new therapeutic avenues settling on the gained knowledge on the role of R3oGE in cancer. To this end scientists participating in the RTG1591 at the MLU and recently recruited colleagues of the medical faculty of the MLU plan to join efforts with colleagues located at research institutions in Leipzig. In retro perspective, the RTG1591 had a substantial, trend-setting impact on establishing and evolving training concepts for graduate students and significantly contributed to establishing a competitive research framework in the central German region. This future investment of the DFG set the stage to proceed and establish research efforts aiming at implementing insights gained or initiated by the RTG1591 to pursue new applications in agriculture and medicine.

Publications

• A novel family of plasmid-transferred anti-sense ncRNAs. (2010) RNA Biol.
  Findeiß, S., Schmidtke, C., Stadler, P.F. and Bonas, U.
  (See online at https://doi.org/10.4161/rna.7.2.11184)
• Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. (2010) Oncogene
  Braun J, Hoang-Vu C, Dralle H, Hüttelmaier S
  (See online at https://doi.org/10.1038/onc.2010.169.)
• Arginine methylation of the nuclear poly(a) binding protein weakens the interaction with its nuclear import receptor, transportin. (2011) J Biol Chem.
  Fronz, K., Guttinger, S., Burkert, K., Kuhn, U., Stohr, N., Schierhorn, A. and Wahle, E.
  (See online at https://doi.org/10.1074/jbc.M111.273912)
• Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1. (2011) Arterioscler Thromb Vasc Biol.
  Schreier, B., Dohler, M., Rabe, S., Schneider, B., Schwerdt, G., Ruhs, S., Sibilia, M., Gotthardt, M., Gekle, M. and Grossmann, C.
  (See online at https://doi.org/10.1161/ATVBAHA.111.223537)
• Linkage of microRNA and proteome-based profiling data sets: a perspective for the priorization of candidate biomarkers in renal cell carcinoma? (2011) J Proteome Res.
  Seliger, B., Jasinski, S., Dressler, S.P., Marincola, F.M., Recktenwald, C.V., Wang, E. and Lichtenfels, R.
  (See online at https://doi.org/10.1021/pr1011137)
• Pathogenic mechanisms of deregulated microRNA expression in thyroid carcinomas of follicular origin. (2011) Thyroid Research.
  Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S
  (See online at https://doi.org/10.1186/1756-6614-4-S1-S1)
• Scratch assay analysis with topology-preserving level sets and texture measures. Proc. of 5th Iberian Conference on Pattern Recognition and Image Analysis (IbPRIA '11), (2011) pages 100-108, Gran Canaria, Spain
  Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S
  (See online at https://doi.org/10.1007/978-3-642-21257-4_13)
• Cell migration analysis: Segmenting scratch assay images with level sets and support vector machines. (2012) Pattern Recognition
  Glaß M, Möller B, Zirkel A, Wächter K, Hüttelmaier S, Posch S
  (See online at https://doi.org/10.1016/j.patcog.2012.03.001)
• Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. (2012) Nucleic Acids Res.
  Schmidtke, C., Findeiß, S., Sharma, C.M., Kuhfuss, J., Hoffmann, S., Vogel, J., Stadler, P.F. and Bonas, U.
  (See online at https://doi.org/10.1093/nar/gkr904)
• Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. (2012) Nucleic Acids Res.
  Schmidtke, C., Findeiß, S., Sharma, C.M., Kuhfuss, J., Hoffmann, S., Vogel, J., Stadler, P.F. and Bonas, U.
  (See online at https://doi.org/10.1093/nar/gkr904)
• HER-2/neu-mediated down-regulation of biglycan associated with altered growth properties. (2012) J Biol Chem.
  Recktenwald, C.V., Leisz, S., Steven, A., Mimura, K., Muller, A., Wulfanger, J., Kiessling, R. and Seliger, B.
  (See online at https://doi.org/10.1074/jbc.M111.334425.)
• IGF2BP1 promotes cell migration by regulating K5 and PTEN signaling. (2012) Genes Dev
  MStohr, N., Kohn, M., Lederer, M., Glass, M., Reinke, C., Singer, R.H. and Huttelmaier, S.
  (See online at https://doi.org/10.1101/gad.177642.111)
• IGF2BP1: a post-transcriptional "driver" of tumor cell migration. (2012) Cell Adh Migr.
  Stohr, N. and Huttelmaier, S.
  (See online at https://doi.org/10.4161/cam.20628)
• Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. (2012) RNA
  Berndt, H., Harnisch, C., Rammelt, C., Stohr, N., Zirkel, A., Dohm, J.C., Himmelbauer, H., Tavanez, J.P., Huttelmaier, S. and Wahle, E.
  (See online at https://doi.org/10.1261/rna.032292.112)
• Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. (2012) RNA
  Berndt, H., Harnisch, C., Rammelt, C., Stohr, N., Zirkel, A., Dohm, J.C., Himmelbauer, H., Tavanez, J.P., Huttelmaier, S. and Wahle, E.
  (See online at https://doi.org/10.1261/rna.032292.112)
• Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. (2012) RNA
  Berndt, H., Harnisch, C., Rammelt, C., Stohr, N., Zirkel, A., Dohm, J.C., Himmelbauer, H., Tavanez, J.P., Huttelmaier, S. and Wahle, E.
  (See online at https://doi.org/10.1261/rna.032292.112)
• Optimizing the enrichment of cross-linked products for mass spectrometric protein analysis. (2012) Rapid Commun Mass Spectrom
  Fritzsche, R., Ihling, C.H., Götze, M., and Sinz, A. .
  (See online at https://doi.org/10.1002/rcm.6150)
• Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1. (2012) J Biol Chem.
  Eiseler, T., Kohler, C., Nimmagadda, S.C., Jamali, A., Funk, N., Joodi, G., Storz, P. and Seufferlein, T.
  (See online at https://doi.org/10.1074/jbc.M112.370999)
• StavroX--a software for analyzing crosslinked products in protein interaction studies. (2012) Journal of the American Society for Mass Spectrometry
  Gotze, M., Pettelkau, J., Schaks, S., Bosse, K., Ihling, C.H., Krauth, F., Fritzsche, R., Kuhn, U., and Sinz, A.
  (See online at https://doi.org/10.1007/s13361-011-0261-2)
• The role of classical and non-classical HLA class I antigens in human tumors. (2012) Semin Cancer Biol.
  Bukur, J., Jasinski, S. and Seliger, B.
  (See online at https://doi.org/10.1016/j.semcancer.2012.03.003)
• TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members. (2012) PLoS One
  Bell JL, Malyukova A, Holien JK, Koach J, Parker MW, Kavallaris M, Marshall GM, Cheung BB
  (See online at https://doi.org/10.1371/journal.pone.0037470)
• A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis. (2013) Oncogene
  Armacki, M., Joodi, G., Nimmagadda, S.C., de Kimpe, L., Pusapati, G.V., Vandoninck, S., Van Lint, J., Illing, A. and Seufferlein, T.
  (See online at https://doi.org/10.1038/onc.2013.43)
• AGO/RISC-mediated antiviral RNA silencing in a plant in vitro system. (2013) Nucleic acids research
  Schuck, J., Gursinsky, T., Pantaleo, V., Burgyan, J., and Behrens, S.E.
  (See online at https://doi.org/10.1093/nar/gkt193)
• AGO/RISC-mediated antiviral RNA silencing in a plant in vitro system. (2013) Nucleic acids research
  Schuck, J., Gursinsky, T., Pantaleo, V., Burgyan, J., and Behrens, S.E.
  (See online at https://doi.org/10.1093/nar/gkt193)
• FMRP regulates actin filament organization via the armadillo protein p0071. (2013) RNA
  Nolze A., Schneider J., Keil R., Lederer M, Hüttelmaier S, Kessels MM, Qualmann B, Hatzfeld M
  (See online at https://doi.org/10.1261/rna037945.112)
• HER-2/neu mediates oncogenic transformation via altered CREB expression and function. (2013) Molecular cancer research
  Steven, A., Leisz, S., Massa, C., Iezzi, M., Lattanzio, R., Lamolinara, A., Bukur, J., Muller, A., Hiebl, B., Holzhausen, H.J., and Seliger, B.
  (See online at https://doi.org/10.1158/1541-7786.MCR-13-0125)
• Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. (2013) The Journal of biological chemistry
  Buschmann, J., Moritz, B., Jeske, M., Lilie, H., Schierhorn, A., and Wahle, E.
  (See online at https://doi.org/10.1074/jbc.M112.426700)
• IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). (2013) Nucleic Acids Res.
  Nikolaos (MD) Zirkel, A., Lederer, M., Stohr, N., Pazaitis, N. and Huttelmaier, S.
  (See online at https://doi.org/10.1093/nar/gkt410)
• IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). (2013) Nucleic Acids Res.
  Anne Zirkel, A., Lederer, M., Stohr, N., Pazaitis, N. and Huttelmaier, S.
  (See online at https://doi.org/10.1093/nar/gkt410)
• IGF2BP1 promotes mesenchymal cell properties and migration of tumor-derived cells by enhancing the expression of LEF1 and SNAI2 (SLUG). (2013) Nucleic Acids Res.
  Zirkel, A., Lederer, M., Stohr, N., Pazaitis, N. and Huttelmaier, S
  (See online at https://doi.org/10.1093/nar/gkt410)
• Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? (2013) Cell Mol Life Sci.
  Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S
  (See online at https://doi.org/10.1007/s00018-012-1186-z)
• Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? (2013) Cell Mol Life Sci.
  Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, Hüttelmaier S
  (See online at https://doi.org/10.1007/s00018-012-1186-z.)
• Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. (2013) Hypertension
  Schreier, B., Rabe, S., Schneider, B., Bretschneider, M., Rupp, S., Ruhs, S., Neumann, J., Rueckschloss, U., Sibilia, M., Gotthardt, M. et al.
  (See online at https://doi.org/10.1161/HYPERTENSIONAHA.112.196543)
• Small RNA sX13: a multifaceted regulator of virulence in the plant pathogen Xanthomonas. (2013) PLoS Pathog.
  Schmidtke, C., Abendroth, U., Brock, J., Serrania, J., Becker, A. and Bonas, U.
  (See online at https://doi.org/10.1371/journal.ppat.1003626)
• Small RNA sX13: a multifaceted regulator of virulence in the plant pathogen Xanthomonas. (2013) PLoS Pathog.
  Schmidtke, C., Abendroth, U., Brock, J., Serrania, J., Becker, A. and Bonas, U.
  (See online at https://doi.org/10.1371/journal.ppat.1003626)
• Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA-binding proteins) is modulated by distinct RNA-binding domains. (2013) Biol Chem.
  Wachter, K., Kohn, M., Stohr, N. and Huttelmaier, S.
  (See online at https://doi.org/10.1515/hsz-2013-0111)
• Transcription factor C/EBPalpha-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia. (2013) Blood
  Katzerke, C., Madan, V., Gerloff, D., Brauer-Hartmann, D., Hartmann, J.U., Wurm, A.A., Muller-Tidow, C., Schnittger, S., Tenen, D.G., Niederwieser, Behre G.
  (See online at https://doi.org/10.1182/blood-2012-12-472183)
• TRIM16 inhibits neuroblastoma cell proliferation through cell cycle regulation and dynamic nuclear localization. (2013) Cell Cycle
  Bell JL, Malyukova A, Kavallaris M, Marshall GM, Cheung BB
  (See online at https://doi.org/10.4161/cc.23825)
• Why YRNAs? About Versatile RNAs and Their Functions. (2013) Biomolecules
  Köhn M, Pazaitis N, Hüttelmaier S.
  (See online at https://doi.org/10.3390/biom3010143)
• (2014). Smaug destroys a huge treasure. Genome biology 15, 101
  Götze, M., and Wahle, E.
  (See online at https://doi.org/10.1186/gb4156)
• Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE). (2014) PLoS One
  Renner, I., Funk, N., Geissler, R., Friedrich, S., Penzel, A., and Behrens, S.E.
  (See online at https://doi.org/10.1371/journal.pone.0114288)
• Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE). (2014) PLoS One
  Renner, I., Funk, N., Geissler, R., Friedrich, S., Penzel, A., and Behrens, S.E.
  (See online at https://doi.org/10.1371/journal.pone.0114288)
• AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genome. (2014) J Virol
  Friedrich, S., Schmidt, T., Geissler, R., Lilie, H., Chabierski, S., Ulbert, S., Liebert, U.G., Golbik, R.P., and Behrens, S.E.
  (See online at https://doi.org/10.1128/JVI.01283-14)
• Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. (2014) PloS one
  Monecke, T., Buschmann, J., Neumann, P., Wahle, E., and Ficner, R.
  (See online at https://doi.org/10.1371/journal.pone.0090915)
• Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. (2014 ) J Natl Cancer Inst.
  Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, Wong M, Liu B, Bell JL, Zhang XD, Milazzo G, Cheung BB, Fox A, Swarbrick A, Hüttelmaier S, Kavallaris M, Perini G, Mattick JS, Dinger ME, Liu T
  (See online at https://doi.org/10.1093/jnci/dju113)
• Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. (2014) J Biol Chem.
  Jasinski-Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, Braun J, Seliger B
  (See online at https://doi.org/10.1074/jbc.M114.556290)
• Identification of 14-3-3β gene as a novel miR-152 target using a proteome-based approach. (2014) J Biol Chem.
  Jasinski-Bergner S, Stehle F, Gonschorek E, Kalich J, Schulz K, Huettelmaier S, Braun J, Seliger B
  (See online at https://doi.org/10.1074/jbc.M114.556290)
• Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. (2014) Hepatology
  Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S
  (See online at https://doi.org/10.1002/hep.26997)
• Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma. (2014) Hepatology
  Gutschner T, Hämmerle M, Pazaitis N, Bley N, Fiskin E, Uckelmann H, Heim A, Groβ M, Hofmann N, Geffers R, Skawran B, Longerich T, Breuhahn K, Schirmacher P, Mühleck B, Hüttelmaier S, Diederichs S
  (See online at https://doi.org/10.1002/hep.26997)
• Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). (2014) Nucleic Acids Res.
  Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S
  (See online at https://doi.org/10.1093/nar/gku127)
• Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). (2014) Nucleic Acids Res.
  Braun J, Misiak D, Busch B, Krohn K, Hüttelmaier S
  (See online at https://doi.org/10.1093/nar/gku127)
• Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. (2014) Genes & Development
  Schönemann, L., Kühn, U., Martin, G., Schäfer, P., Gruber, A. R., Keller, W., Zavolan, M., Wahle, E.
  (See online at https://doi.org/10.1101/gad.250985.114)
• Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. (2014) Genes & Development
  Schönemann, L., Kühn, U., Martin, G., Schäfer, P., Gruber, A. R., Keller, W., Zavolan, M., Wahle, E.
  (See online at https://doi.org/10.1101/gad.250985.114)
• Small non-coding RNAs in plant-pathogenic Xanthomonas spp. (2014) RNA Biology
  Abendroth, U., Schmidtke, C. and Bonas, U.
  (See online at https://doi.org/10.4161/rna.28240)
• Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation. (2014) J Transl Med
  Quandt D, Jasinski-Bergner S, Müller U, Schulze B, Seliger B
  (See online at https://doi.org/10.1186/1479-5876-12-151)
• The armadillo protein p0071 is involved in Rab11-dependent recycling. (2014) J Cell Sci.
  René Keil, R. and M. Hatzfeld
  (See online at https://doi.org/10.1242/jcs.132266)
• The role of microRNAs in the control of innate immune response in cancer. (2014) J Natl Cancer Inst.
  Jasinski-Bergner S, Mandelboim O, Seliger B
  (See online at https://doi.org/10.1093/jnci/dju257)
• The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. (2014) Semin Cancer Biol.
  Lederer M, Bley N, Schleifer C, Hüttelmaier S
  (See online at https://doi.org/10.1016/j.semcancer.2014.07.006)
• (2015). VHL-dependent alterations in the secretome of renal cell carcinoma: Association with immune cell response? Oncotarget 6, 43420-43437
  Stehle, F., Leisz, S., Schulz, K., Schwurack, N., Weber, N., Massa, C., Kalich, J., Fahldieck, C., and Seliger, B.
  (See online at https://doi.org/10.18632/oncotarget.5560)
• Automated assignment of MS/MS cleavable cross-links in protein 3D-structure analysis. (2015) Journal of the American Society for Mass Spectrometry
  Götze, M., Pettelkau, J., Fritzsche, R., Ihling, C.H., Schafer, M., and Sinz, A.
  (See online at https://doi.org/10.1007/s13361-014-1001-1)
• Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. (2015) Oncoimmunology
  Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B
  (See online at https://doi.org/10.1080/2162402X.2015.1008805)
• Clinical relevance of miR-mediated HLA-G regulation and the associated immune cell infiltration in renal cell carcinoma. (2015) Oncoimmunology
  Jasinski-Bergner S, Stoehr C, Bukur J, Massa C, Braun J, Hüttelmaier S, Spath V, Wartenberg R, Legal W, Taubert H, Wach S, Wullich B, Hartmann A, Seliger B
  (See online at https://doi.org/10.1080/2162402X.2015.1008805)
• Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism. (2015) Oncotarget
  Leisz, S., Schulz, K., Erb, S., Oefner, P., Dettmer, K., Mougiakakos, D., Wang, E., Marincola, F.M., Stehle, F., and Seliger, B.
  (See online at https://doi.org/10.18632/oncotarget.3456)
• Homeologs of the Nicotiana benthamiana Antiviral ARGONAUTE1 Show Different Susceptibilities to microRNA168-Mediated Control. (2015) Plant Physiol
  Gursinsky, T., Pirovano, W., Gambino, G., Friedrich, S., Behrens, S.E., and Pantaleo, V.
  (See online at https://doi.org/10.1104/pp.15.00070)
• Homeologs of the Nicotiana benthamiana Antiviral ARGONAUTE1 Show Different Susceptibilities to microRNA168-Mediated Control. (2015) Plant Physiol
  Gursinsky, T., Pirovano, W., Gambino, G., Friedrich, S., Behrens, S.E., and Pantaleo, V.
  (See online at https://doi.org/10.1104/pp.15.00070)
• IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma. (2015 ) J Clin Oncol.
  Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S
  (See online at https://doi.org/10.1200/JCO.2014.55.9880)
• IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in Neuroblastoma. (2015 ) J Clin Oncol.
  Bell JL, Turlapati R, Liu T, Schulte JH, Hüttelmaier S
  (See online at https://doi.org/10.1200/JCO.2014.55.9880)
• Mitochondrial poly(A) polymerase is involved in tRNA repair.(2015) Nucleic acids research
  Fiedler, M., Rossmanith, W., Wahle, E., and Rammelt, C.
  (See online at https://doi.org/10.1093/nar/gkv891)
• NF-kappaB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia. (2015) Leukemia
  Gerloff, D., Grundler, R., Wurm, A.A., Brauer-Hartmann, D., Katzerke, C., Hartmann, J.U., Madan, V., Muller-Tidow, C., Duyster, J., Tenen, D.G., Niederwieser, D., and Behre, G.
  (See online at https://doi.org/10.1038/leu.2014.231)
• The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics. (2015) Proceedings of the National Academy of Sciences of the United States of America
  Elbaum-Garfinkle, S., Kim, Y., Szczepaniak, K., Chen, C.C., Eckmann, C.R., Myong, S., and Brangwynne, C.P.
  (See online at https://doi.org/10.1073/pnas.1504822112)
• Translation activation maintains germline tissue homeostasis during adulthood. (2015) Worm
  Nousch M. and C.R. Eckmann
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• WDR5 supports an N-Myc transcriptional complex that drives a pro-tumorigenic gene expression signature in neuroblastoma. (2015) Cancer Res.
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