SFB 858:  Synergetic Effects in Chemistry - From Additivity towards Cooperativity

• Subject Area: Chemistry ; Biology ; Social and Behavioural Sciences
• Term: from 2010 to 2021
• Website: Homepage
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 104405829

The CRC 858 applies cooperative effects to the construction and activation of chemical systems in an interdisciplinary approach, aiming at evolving the term cooperativity into a general principle in particular for chemical sciences. Cooperative effects will allow steering chemical reactivity to a higher degree of efficiency and understanding how chemical structures can be constructed in a well-defined manner. These goals are explored at two levels: at the molecular level cooperative effects are investigated on smaller defined compounds which can be well characterized by analytical techniques and by computational methods. At the systemic level, complex structures are investigated, including surface determined processes, covering synthetic inorganic materials as well as bio systems. All research fields are linked by theoretical chemistry. In all systems studied cooperative interactions exerted by individual chemical entities lead to an outcome which is different from the sum of the impacts of all individual entities.One hot topic within the CRC 858 is the chemistry of frustrated Lewis acid / -base pairs (FLPs) for the development of novel chemical reactions. In bi- and multi metallic systems cooperative effects of interacting metals in organometallic compounds are studied, including established ligand structures and unconventional ligands like DNA. This area now is extended towards the preparation of nanoclusters and their application in catalysis, therefore important contributions to the field of heterogeneous catalysis have been made. In pioneering contributions surfaces are exploited as platforms for (pre)organisation and as mediators for the conduction of 2D chemical reactions, where the surface acts cooperatively as steering factor for the discrete arrangement of individual molecules and as catalyst for the bond forming reaction. Magnetism arises from cooperative interactions of individual atoms or molecules. CRC contributes to this by construction of organic polyspin systems, synthesized and analyzed based on theoretical predictions. Cooperativity is a key issue for function in various biological systems, e.g. when modulating the surface of dynamic biomembranes. With combined theoretical and experimental methods the CRC investigates weak cooperative interactions as driving forces for protein-protein and protein-carbohydrate recognition. Furthermore, protein-protein and protein-RNA interactions are studied by chemically conjugating proteins and by installing synthetic probes.The CRC 858 bundles fundamental aspects of cooperativity, a term that cumulatively is used in chemistry and physics. The researchers develop general concepts in order to contribute to a generally accepted perception of the term cooperativity. With its participating institutions the University of Münster offers together with the Center for Nanotechnology (CeNTech) an ideal infrastructure for interdisciplinary research on Synergistic Effects in Chemistry.

• DFG Programme: Collaborative Research Centres
• International Connection: Austria

Completed projects

• A01 - Cooperative Reactions of "non quenching" Lewis-Acid/-Base Pairs with unsaturated Substrates (Project Heads Eckert, Hellmut ;  Erker, Gerhard )
• A02 - Compounds Consisting of Group 13 Lewis Acids and Nitrogen based Lewis Bases for Bifunctional Activation (Project Heads Eckert, Hellmut ;  Uhl, Werner )
• A03 - Reversible Stabilization of Silicon-Stereogenic Silylium Ions in Enantioselective Lewis Acid Catalysis (Project Head Oestreich, Martin )
• A04 - Cooperative Asymmetric Catalysis with Heterobimetallic Systems (Project Head Garcia Mancheno, Olga )
• A05 - Olefin Ligands in Cooperative Catalysis (Project Head Glorius, Frank )
• A06 - Amphiphilic Tetrylenes in (asymmetric) Catalysis (Project Heads Glorius, Frank ;  Hahn, F. Ekkehardt )
• A07 - Heteropolynuclear Carbene Complexes with Cooperatively Interacting Metal Centers (Project Head Hahn, F. Ekkehardt )
• A08 - Cooperative Reactivity of Metal Atoms in Polynuclear Transition Metal Polyhydrides (Project Head Wolf, Robert )
• A09 - Are Stereoelectronic Effects Additive or Cooperative? (Project Head Gilmour, Ryan )
• A10 - Imidazolin-2-ylidenaminophosphines as Cooperative Ligands for the Activation of Strong σ Bonds (Project Head Dielmann, Fabian )
• A12 - Cooperative Triazole H-Donors in Asymmetric Dearomatization by Anion-Binding Catalysis (Project Head Garcia Mancheno, Olga )
• B01 - Cooperative Catalysis at Nanoparticle Surfaces (Project Head Studer, Armido )
• B02 - 2D Reactions at Surfaces (Project Heads Fuchs, Harald ;  Studer, Armido )
• B03 - Understanding N-Heterocyclic Carbenes on Metal Surfaces – Properties & Applications (Project Heads Chi, Lifeng ;  Erker, Gerhard ;  Fuchs, Harald ;  Glorius, Frank )
• B04 - Cooperativity of Membrane Lipid Domain Organization Mediated by Peripherally Associated Proteins: Principles and Visualization (Project Heads Galla, Hans Joachim ;  Gerke, Volker ;  Glorius, Frank ;  Heuer, Andreas )
• B05 - Functional Regulation of ABC Transporters of the Multi-Drug- Resistance by Cooperative Interactions (Project Heads Galla, Hans Joachim ;  Studer, Armido )
• B06 - Biomimetic Molecular Recognition of Carbohydrates and Peptides (Project Head Ravoo, Bart Jan )
• B07 - Thermodynamic and Dynamic Equillibrium of Fluid-Fluid-Phases in Membrane Lipids (Project Head Heuer, Andreas )
• B08 - DNA as Chiral Element of Organization for Catalysts in Aqueous Media (Project Head Hennecke, Ulrich )
• B09 - Cooperative Effects in Metal-Modified DNA (Project Head Müller, Jens )
• B11 - Cooperativity in Organic Spin Materials and their Hybrid Systems: Steering of Magnetic Properties by Orientation of Radicals (Project Heads Eckert, Hellmut ;  Studer, Armido )
• B12 - Multiscale Modelling of Cooperativity in Complex Molecular Systems (Project Head Waller, Mark P. )
• B13 - Molecular Basis for the Cooperative Action of the Reverse Gyrase Helicase and Topoisomerase Domains in Positive DNA Supercoiling (Project Head Klostermeier, Dagmar )
• B14 - New Protein Chemical Tools for the Analysis of Cooperative Effects within Protein Interactions mediated by Ubiquitin-like Modifiers (Project Head Mootz, Henning D. )
• B15 - Innovative Ligands at Nanoparticles and at Surfaces (Project Heads Glorius, Frank ;  Ravoo, Bart Jan )
• B16 - Controlling photoluminescent properties in the self-assembly of peptidic Au(I)-Metalloamphiphiles through cooperative interactions (Project Head Besenius, Pol )
• B17 - Disentangling the Cooperative Effects of Multiple Non-Covalent Interactions in BODIPY-based Self-Assembled Structures (Project Heads Fernandez-Huertas, Gustavo ;  Hansen, Michael Ryan )
• B18 - Chemo-enzymatic Manipulation of RNA: Sequence-specifity via Cooperative Effects (Project Head Rentmeister, Andrea )
• B19 - Self-Assembled Polymer Nanocontainers – Stimuli Responsive Systems for Controlled Drug Release and Cooperative Catalysis (Project Heads Gerke, Volker ;  Ravoo, Bart Jan ;  Studer, Armido )
• MGK - Principles and Applications of Cooperative Systems (Project Heads Glorius, Frank ;  Tebben, Ludger )
• Z01 - Computational Chemistry (Theory and Modeling of Cooperativity in Chemical Systems) (Project Heads Doltsinis, Nikos L. ;  Heuer, Andreas ;  Mück-Lichtenfeld, Christian ;  Neugebauer, Johannes ;  Waller, Mark P. )
• Z02 - Central Administration and Central Tasks of the Collaborative Research Centre (SFB) 858 (Project Heads Glorius, Frank ;  Studer, Armido ;  Tebben, Ludger )
• Z03 - How to communicate and mediate Chemistry? - Development and Evaluation of a Vocational Preparation Seminar (Project Head Marohn, Anette )

• Applicant Institution: Universität Münster
• Spokesperson: Professor Dr. Armido Studer