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Professor Dr. Jacob Piehler

Address Universität Osnabrück
Fachbereich Biologie / Chemie
Arbeitsgruppe Biophysik
Barbarastraße 11
49076 Osnabrück

ORCID-ID 0000-0002-2143-2270

Projects

As Applicant
- Current projects
  - Role of the membrane environment in the activation and dysregulation of JAK2 (Research Grants)
- Completed projects
  - Biophysical characterization of the functional assembly of cytokine receptors (Independent Junior Research Groups)
  - Modular assembly of functional transmembrane units in polymer-supported lipid bilayers (Research Units)
  - Biophysikalische Chemie (Heisenberg Professorships)
  - ERA NANOSCI: Observation and manipulation of individual type I interferon signalling complexes (Research Grants)
  - Dynamics of type I interferon receptor assembly (Research Grants)
  - Biophysikalische Chemie (Heisenberg Fellowships)
  - The role of spatio-temporal nano-organization in regulating the specificity of JAK/STAT signaling (Research Grants)
  - Integrated bioimaging facility for resolving the nanoscale cell biology (iBIOS) (Core Facilities)
  - Integrated microstructures for label-free interrogation of protein conformational dynamics by plasmon-enhanced THz spectroscopy (Priority Programmes)
As Leader
- Completed projects
  - Rasterkraftmikroskop (Major Research Instrumentation)
  - Laserscanning-Mikroskop (LSM mit FLIM-Modul) (Major Research Instrumentation)
  - Transmissionselektronenmikroskop (Major Research Instrumentation)
  - Three-dimensional imaging of cells and tissues with ultrahigh spatiotemporal resolution by lattice light sheet microscopy (Major Instrumentation Initiatives)
  - High Content Live Cell Screening Fluorescence Microscope (Major Research Instrumentation)
As Spokesperson
- Current projects
  - GRK 2900: nanomaterials@biomembranes: Rationally designed surface architectures for nanoscale interrogation and manipulation of biomolecules at membranes (Research Training Groups)
As Project Head
- Current projects
  - Regulation of cytokine receptor signaling plasticity by the subcellular membrane context (Collaborative Research Centres)
  - Plasticity of GSDM pores for the control of pyroptotic cell death (Collaborative Research Centres)
- Completed projects
  - Dynamics of Type I-Interferon Receptor Assembly (Collaborative Research Centres)
  - Dynamics of Type I Interferon Receptor Assembly (Collaborative Research Centres)
  - Molecular and cellular regulation of JAK/STAT signaling (Collaborative Research Centres)
  - Advanced imaging techniques (Collaborative Research Centres)
As Cooperation Partner
- Completed projects
  - Molecular determinants of ligand binding and signaling of the activating receptor NKp30 on natural killer cells (Research Grants)

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