Project Details

Professor Dr. Harald Schwalbe

Address Goethe-Universität Frankfurt am Main
Fachbereich Biochemie, Chemie und Pharmazie
Institut für Organische Chemie und Chemische Biologie
Max-von-Laue-Straße 7
60438 Frankfurt am Main

ORCID-ID 0000-0001-5693-7909

Projects

As Applicant
- Current projects
  - Effects of glycosylation on protein structure, function and dynamics (Research Units)
  - Nanoseond Ultra-Rapid Freeze Quenching for Time-resolved Structural Biology (New Instrumentation for Research)
  - NMR and biophysical characterization of structure and dynamics of µ-proteins and their complexes. (Priority Programmes)
  - SARS-CoV-2-RNA: Understanding the RNA architecture of SARS-CoV-2 (Research Grants)
  - in-cell NMR of DNA G4 - structure and folding (Research Grants)
  - Improvement of the NMR structural quality for RNA and DNA (Research Grants)
- Completed projects
  - Strukturelle Charakterisierung der human accelerated region 1 RNA vonMensch und Schimpansen (Research Grants)
  - NMR Investigation of the Regulation of Gene Expression by RNA Thermometers (Priority Programmes)
  - Elucidation of the mechanism of aggregation of disease-associated single point mutants of the murine prion protein on the basis of time-resolved 2D NMR spectroscopy in combination with complementary kinetic methods (Research Grants)
  - Network of German NMR centres (G-NMR) (Research Grants)
  - Effects of glycosylation on protein structure, function and dynamics (Research Units)
  - Structure, dynamics and kinetics of folding of G-quadruplex nucleic acids (Research Grants)
  - Dynamic basis of the molecular mechanism of nucleotide secondary messengers-sensing riboswitches by NMR spectroscopy (Priority Programmes)
As Leader
- Completed projects
  - 950 MHz NMR-Spektrometer (Major Research Instrumentation)
  - 500 MHz Kernresonanzspektrometer (Major Research Instrumentation)
  - Konsole für 600 MHz Kernresonanzspektrometer (Major Research Instrumentation)
  - NMR-Austauschkonsole 700 MHz mit fünf Kanälen (Major Research Instrumentation)
  - NMR-Austauschkonsole 800 MHz mit vier Kanälen (Major Research Instrumentation)
  - Laseranlage zur Bestrahlung von NMR-Proben im Magneten (Major Research Instrumentation)
  - NMR-Austauschkonsole für 600 MHz Spektrometer (Major Research Instrumentation)
  - NMR console (replacement) for 600 MHz spectrometer, cryogenic cooling platform and 19F probe head. (Major Research Instrumentation)
As Spokesperson
- Completed projects
  - SFB 579: RNA-Ligand Interactions (Collaborative Research Centres)
  - EXC 115: Macromolecular Complexes (Clusters of Excellence)
  - SFB 902: Molecular Principles of RNA-based Regulation (Collaborative Research Centres)
As Participating Researcher
- Completed projects
  - GRK 1986: Complex Scenarios of Light-Control (Research Training Groups)
As Project Head
- Current projects
  - Modulation of tyrosine receptor signaling investigated by NMR spectroscopy (Collaborative Research Centres)
  - Vascular gene expression control through DNA:DNA:RNA triplex-formation by lncRNAs (CRC/Transregios)
- Completed projects
  - High Resolution Spectroscopy Investigations of T-Cell Activation and G Protein Coupled Receptors (Collaborative Research Centres)
  - Organic Synthesis of photolabile cofactors and NMR investigation of antibody fragments reporting Rieske domain movements of the bc1 complex (Collaborative Research Centres)
  - NMR Investigations of Mammalian Rhodopsin and of Membrane-associated Protein GARP2 (Collaborative Research Centres)
  - NMR-spectroscopic investigations of RNA and RNA-Ligand-Complexes (Collaborative Research Centres)
  - Zentrale Verwaltung des SFB (Collaborative Research Centres)
  - NMR investigations of retinal binding proteins (Collaborative Research Centres)
  - Conformational dynamics of RNA regulation elements studied by NMR spectroscopy (Collaborative Research Centres)
  - Central Tasks of the Collaborative Research Centre (Collaborative Research Centres)
  - Structural Biology of SARS-CoV-2 by NMR spectroscopy (Covid19-NMR) (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Höchstfeld-NMR-Spektroskopie an Biomakromolekülen (Research Grants)
  - Solid-state NMR Spectroscopy on Biomolecular Complexes at Lowest Temperatures and Highest Fields (Research Grants)
As Cooperation Partner
- Completed projects
  - Cations in charge of RNA folding and function: Realistic modeling and robust predictions (Independent Junior Research Groups)
As Co-Applicant
- Completed projects
  - Development of Biomolecular High Field Pulsed DNP and cwDNP MAS-NMR Applications (Major Instrumentation Initiatives)

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Hauptnavigation

Professor Dr. Harald Schwalbe

Additional Information

Servicenavigation

Hauptnavigation

Professor Dr. Harald Schwalbe

Additional Information

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