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Professor Dr. Marcus Groettrup (†)

Projects

As Applicant
- Completed projects
  - NUB-1 - a new interaction partner of the ubiquitin-like protein FAT10 with a novel function in proteolytic targeting (Research Grants)
  - Proteasome molecular composition, biosynthesis, turnover and function during viral infection (Research Grants)
  - The Mechanisms of cross-presentation of a long-lived viral protein (Research Grants)
  - Localization and intracellular trafficking of the chemokine receptor CCR7 after ligand mediated signal transduction and chemotaxis (Research Grants)
  - The function of UBEIL2, a novel ubiquitin specific activating enzyme (E1) (Research Grants)
  - Molecular regulation and functional efficacy of T cell responses in a mouse model of social stress and patients with post-traumatic stress disorder (PTSD) (Research Units)
  - The ubiquitin-like modifier FAT10 in autophagosomal targeting (Research Grants)
  - The function of immunoproteasomes in cytokine production and autoimmune diseases (Research Grants)
  - The role of the ubiquitin-like protein FAT10 in thymic selection (Priority Programmes)
  - Identification of Immunoproteasome dependent factors involved in cytokine release and T cell differentiation (Research Grants)
As Leader
- Completed projects
  - Durchflusszytometer (5 Laser) (Major Research Instrumentation)
As Participating Researcher
- Current projects
  - EXC 2117: Centre for the Advanced Study of Collective Behaviour (Clusters of Excellence (ExStra))
- Completed projects
  - GRK 702: Biomedical Drug Research (Research Training Groups)
  - GRK 1331: Cell-based Characterisation of Disease Mechanisms in Tissue Destruction and Repair (Research Training Groups)
  - GSC 218: Konstanz Research School Chemical Biology (KoRS-CB) (Graduate Schools)
As Project Head
- Completed projects
  - Regulation of CCR7 signalling and lipid raft association in dendritic cells through prostaglandin E2 (CRC/Transregios)
  - Localization and intracellular trafficking of the chemokine receptor CCR7 after ligand mediated signal transduction and chemotaxis (CRC/Transregios)
  - The substrates of FAT10ylation and their proteolytic targeting (Collaborative Research Centres)
  - The structural and functional consequences of FAT10 phosphorylation (Collaborative Research Centres)
As Participating Person
- Completed projects
  - Development of a prostate cancer DNA-vaccine (Research Grants)
As Ehemaliger Antragsteller
- Current projects
  - Therapy of prostate carcinoma by immunoproteasome inhibition (Research Grants) to 12/2022
- Completed projects
  - Regulation of 26S proteasome activity and coping with protein aggregation diseases by NUB1 (Research Grants) to 9/2022

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