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Institution
Universität Regensburg
Fakultät für Biologie und Vorklinische Medizin
Institut für Biophysik und physikalische Biochemie
Lehrstuhl für Biophysik
Address
93040 Regensburg
Deutschland
GERiT
This institution in GERiT
93040 Regensburg
Projects
Priority Programmes
Current projects
Molecular mechanisms and functional implications of Ded1p phase separation.
(Applicant
Sprangers, Remco
)
Completed projects
High-Field EPR/ENDOR Spectroscopy on Guanine Nucleotide Binding Protein
(Applicant
Kalbitzer, Hans Robert
)
Lösungsstruktur der Ran-Bindungsdomäne von RanBP2 und Protein-Protein-Interaktionenen im Ran-gekoppelten Kerntransportsystem
(Applicant
Kalbitzer, Hans Robert
)
Research Units
Completed projects
Characterization of different conformational states of proteins by highpressure NMR spectroscopy
(Applicants
Kalbitzer, Hans Robert
;
Kremer, Werner
)
FOR 1979: Exploring the Dynamical Landscape of Biomolecular Systems by Pressure Perturbation
(Spokesperson
Winter, Roland
)
Struktur und Funktion viraler Proteine: Nef-Protein von HIV-2
(Applicant
Kalbitzer, Hans Robert
)
Research Grants
Current projects
Correlating dynamics with function in the eukaryotic exoribonuclease enzymes Xrn1 and Xrn2
(Applicant
Sprangers, Remco
)
Insights into functionally important conformational changes in the 400 kDa RNA exosome complex: a combination of methyl TROSY NMR spectroscopy and cryo- EM.
(Applicant
Sprangers, Remco
)
Completed projects
3D-Struktur des Cannulae bildenden Proteins CanA des hyperthermophilen Archaeum Pyrodictium spec. in atomarer Auflösung
(Applicant
Kalbitzer, Hans Robert
)
Characterization of rare conformational states of proteins by combination of high-pressure X-ray crystallography with high-pressure NMR spectroscopy. Application to the small Gprotein Ras, its oncogenic mutants and its drug complexes.
(Applicant
Kalbitzer, Hans Robert
)
Entwicklung einer spektrometergesteuerten Druckapparatur zur Hochdruck-NMR-Spektroskopie für die Untersuchung von konformationellen Intermediaten
(Applicant
Kalbitzer, Hans Robert
)
Festkörper-NMR-spektroskopische Untersuchungen an nucleotidbindenden Proteinen
(Applicant
Brunner, Eike
)
Linkage between catalytic mechanism and conformational dynamics in (beta/alpha)8-barrel enzymes
(Applicant
Sterner, Reinhard
)
Lösungsstruktur der Ras-Bindungsdomäne von Nore1 und strukturelle Charakterisierung der Nore1-Ras-Mst1-Interaktion
(Applicant
Kalbitzer, Hans Robert
)
Molecular mechanisms underlying RNA unwinding by the DEAD-box helicase DbpA
(Applicant
Sprangers, Remco
)
NMR-spektroskopische Aufklärung der räumlichen Struktur der DNA-bindenden Domäne des Proteins ARBP/MeCP2
(Applicant
Brunner, Eike
)
NMR-Strukturuntersuchung des Kälteschockproteins TmCsp aus dem hyperthermophilen Bakterium Thermotoga maritima unter extremen Bedingungen
(Applicant
Kremer, Werner
)
NMR-Struktur von Thioredoxin und Plasmoredoxin von Plasmodium falciparum und Charakterisierung seiner Komplexe mit interagierernden Proteinen
(Applicant
Kalbitzer, Hans Robert
)
Phosphat-Shuttle in der Taxis-Signalkette von S. meliloti: NMR-Strukturanalyse von CheY2 und CheY2-P/CheA
(Applicant
Schmitt, Rüdiger
)
Solution structure of the Ras-binding domain of AF6 and its interaction with the Ras-protein
(Applicant
Kalbitzer, Hans Robert
)
Struktur und Dynamik des Protoonkogens Ras und spezifischer Ras-Mutanten.
(Applicant
Kalbitzer, Hans Robert
)
Collaborative Research Centres
Completed projects
Cdc123-mediated assembly of the translation factor eIF2: mechanism and significance
(Project Heads
Seufert, Wolfgang
;
Sprangers, Remco
)
How do the decapping enzymes DcpS and Dcp2 sense the length of the mRNA substrate?
(Project Head
Sprangers, Remco
)
NMR-structure, dynamics and function of ion channels in the kidney
(Project Head
Kalbitzer, Hans Robert
)
Struktur und Funktion von Proteinen Niederer Eukaryonten
(Project Head
Kalbitzer, Hans Robert
)
CRC/Transregios
Completed projects
Characterization of lipid-dependent conformation intermediates of raft-associatet proteins using NMR spectroscopy
(Project Head
Kalbitzer, Hans Robert
)
Major Research Instrumentation
Completed projects
500 MHz NMR-Spektrometerkonsole mit Probenköpfen
600 MHz NMR-Spektrometerkonsole mit Kryoprobe
800 MHz NMR-Spektrometerkonsole mit Kryoplattform
Research Training Groups
Completed projects
GRK 638: Nonlinearity and Nonequilibrium in Condensed Matter
(Spokesperson
Strunk, Christoph
)
GRK 760: Medicinal Chemistry: Molecular Recognition - Ligand-Receptor Interactions
(Spokesperson
Buschauer, Armin
)
Additional Information
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