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Institution
Universität Leipzig
Medizinische Fakultät
Institut für Medizinische Physik und Biophysik
Address
Härtelstraße 16-18
04107 Leipzig
Deutschland
GERiT
This institution in GERiT
04107 Leipzig
Projects
Independent Junior Research Groups
Completed projects
Studium der Wechselwirkungen antimikrobiell aktiver Peptide mit Membranlipiden in biomimetischen Modellsystemen
(Applicant
Bringezu, Frank
)
Research Grants
Current projects
Disentangling dynamics in biomolecules with experiment and simulation
(Applicant
Smith-Penzel, Ph.D., Albert
)
Investigation of oxidized lipids with (patho)physiological relevance using mass spectrometric methods and their improved detection using MS imaging
(Applicant
Engel, Kathrin
)
New methods for the robust analysis of lipids by coupling thin-layer chromatography with mass spectrometry
(Applicants
Schiller, Jürgen
;
Wiesner, Claudia
)
Novel Insights into the Nanostructure of the Skin Lipid Barrier by Biophysical Methods
(Applicant
Huster, Daniel
)
Plasma Membrane Rigidity Directly Influences Cell Migration
(Applicants
Käs, Josef Alfons
;
Schiller, Jürgen
)
Completed projects
Analysis of the extracellular matrix of bioengineered tendon tissue by means of MALDI-TOF mass spectrometry and NMR spectroscopy.
(Applicant
Nimptsch, Ariane
)
Analytik der extrazellulären Matrix in künstlichem Knorpelgewebe mittels NMR-Spektroskopie und MALDI-TOF-Massenspektrometrie
(Applicants
Bader, Augustinus
;
Huster, Daniel
;
Schiller, Jürgen
)
Bedeutung der Membranverankerung von Proteinen für Protein-Struktur und Wechselwirkungen
(Applicant
Arnold, Klaus
)
Beschaffung eines Kernresonanzspektrometers mit einer magnetischen Induktion von 17,6 T in einem wide-bore-Magnet
(Applicant
Michel, Dieter
)
Characterizing the Interaction of Small-Molecule Kinase Inhibitors with Membranes to Understand their Specific Cellular Effects
(Applicants
Müller, Peter
;
Scheidt, Holger A.
)
Charakterisierung der Struktur und Dynamik des Lipidverankerten C-Terminus des menschlichen Ras-Proteins in Membranen mit Festkörper-NMR- und FTIR-Spektroskopie
(Applicant
Huster, Daniel
)
Deciphering the oxidation status of biomolecules in synovial fluids and tissues acting as damage associated molecular patterns (DAMPs) in rheumatoid arthritis
(Applicants
Hoffmann, Ralf
;
Schiller, Jürgen
;
Wagner, Ulf
)
Determining factors of the toxicity in intestine and liver for two similar sized nanoparticles used in food and packaging: In vitro and in vivo investigation on uptake and mechanisms involved
(Applicants
Estrela-Lopis, Irina
;
Lampen, Alfonso
;
Laux, Peter
)
Einflüsse von Entzündungskaskaden auf Signaltransduktionen in Humanspermien und die Folgen für den Fertilisationsprozess
(Applicant
Glander, Hans-Jürgen
)
Fabrikation und Charakterisierung von kolloidalen Biokompositen unter Verwendung von viralen Bauelementen
(Applicant
Donath, Edwin
)
Functionalization of LbL-Microcarriers as Drug Delivery System for Elastase Inhibitors and HOCl Scavengers for the Termination of Chronic Inflammation
(Applicant
Reibetanz, Uta
)
Identifizierung und Rekonstitution detergenzresistenter Membrandomänen in SÄugerspermien und deren Funktion bei der Befruchtung
(Applicants
Müller, Karin
;
Schiller, Jürgen
)
Investigation of the influence and function of different ceramide subspecies to the nanostructure and the dynamic of Stratum corneum lipid model systems
(Applicants
Brezesinski, Gerald
;
Dobner, Bodo
;
Huster, Daniel
;
Neubert, Reinhard
)
Layer-by-Layer modified DNA Origami Nanostructures as a Smart Tool for Drug Delivery
(Applicant
Reibetanz, Uta
)
Lysophospholipids, species-independent markers of pathological changes of spermatozoa
(Applicants
Müller, Karin
;
Paasch, Uwe
;
Schiller, Jürgen
)
Mechanisms of reaction of hypochlorous acid with organic hydroperoxides
(Applicant
Arnhold, Jürgen
)
Mechanistic Insights into the Specificity of Glycosaminoglycan Interactions with Regulatory Proteins
(Applicant
Huster, Daniel
)
Molecular principles of patho-physiological mechanisms of the incretin receptors with general implications for family B GPCRs
(Applicants
Biebermann, Heike
;
Hildebrand, Peter
;
Tschöp, Matthias
)
Struktur-Funktionsbeziehungen im funktionellen Komplex der membranständigen neuronalen Guanylatzyklase aus Photorezeptoren
(Applicants
Blume, Alfred
;
Huster, Daniel
;
Sinz, Andrea
)
Tertiary structure modelling of active G protein coupled receptor states
(Applicant
Hildebrand, Peter
)
Ultralong Chain Ceramides in Membrane Models of Healthy and Diseased Skin Barrier
(Applicant
Huster, Daniel
)
Collaborative Research Centres
Current projects
Characterizing the molecular interactions between Y receptors and arrestin
(Project Heads
Beck-Sickinger, Annette G.
;
Huster, Daniel
)
Data management and computational models of structure and dynamics, and evolution of GPCRs
(Project Heads
Hildebrand, Peter
;
Meiler, Jens
;
Stadler, Peter Florian
)
Integrated Research Training Group (MGK)
(Project Head
Huster, Daniel
)
Investigation of the structure and dynamics of the ghrelin/GHS receptor complex
(Project Heads
Hildebrand, Peter
;
Huster, Daniel
;
Schoeder, Clara
)
Mechano-sensitive adhesion GPCR in adipose tissue
(Project Heads
Huster, Daniel
;
Liebscher, Ines
;
Schiller, Jürgen
;
Schöneberg, Torsten
)
Proteome and lipidome analysis by mass spectrometry and NMR
(Project Heads
von Bergen, Martin
;
Schiller, Jürgen
)
Specificity and dynamics in signaling of peptide activated GPCRs
(Project Heads
Hildebrand, Peter
;
Stadler, Peter Florian
)
The role of conformational dynamics for Y receptor activation
(Project Heads
Elgeti, Matthias
;
Schmidt, Peter
;
Sinz, Andrea
)
Completed projects
Determination of the Structure and Dynamics of Receptor-Bound Neuropeptide Y using Solid-State NMR Spectroscopy
(Project Head
Huster, Daniel
)
Molekulare Dynamik des makromolekularen Grundgerüstes und der flüssigen Physe in Knorpel und Polymergelen
(Project Head
Arnold, Klaus
)
Molekulare Dynamik vonPolymergerüst, Lösungsmittel und Ionen im Knorpel. Zusammenhänge zum Schwellungsverhalten
(Project Head
Arnold, Klaus
)
Polare Wechselwirkungen makromolekularer Komponenten im Knorpelgewebe und an der Oberfläche
(Project Head
Arnold, Klaus
)
Structural elucidation of the GPCR allosteric machine
(Project Heads
Hildebrand, Peter
;
Scheerer, Patrick
)
CRC/Transregios
Current projects
Flavomaquettes with observer spin label for hyperpo-larized EPR
(Project Heads
Coin, Irene
;
Elgeti, Matthias
;
Meiler, Jens
)
Magnetic resonance imaging with photo-CIDNP signal enhancement
(Project Heads
Alia Matysik, Alia
;
Matysik, Jörg
)
Completed projects
Chemoenzymatic synthesis of defined sulfated oligohyaluronans for binding studies and the construction of artificial extracellular matrices
(Project Heads
Rademann, Jörg
;
Schiller, Jürgen
)
Investigation of the interaction of mediators with matrix components and analysis of the extracellular matrix by NMR methods
(Project Head
Huster, Daniel
)
NMR Investigations of the Self Organization and Dynamics of Amyloid Protein Fibrils
(Project Heads
Balbach, Jochen
;
Huster, Daniel
)
Synthesis and allocation of oligomeric and polymeric glycosaminoglycans and artificial extracellular matrices
(Project Heads
Giannis, Athanassios
;
Scharnweber, Dieter
;
Schiller, Jürgen
;
Schnabelrauch, Matthias
)
Synthesis and characterization of ECM-specific polysaccharides
(Project Heads
Schiller, Jürgen
;
Schnabelrauch, Matthias
)
Major Research Instrumentation
Completed projects
600 MHz Festkörper NMR-Spektrometer
700 MHz-Festkörper-NMR-Konsole mit zwei Probenköpfen
Research Fellowships
Completed projects
Developing a common structural and functional framework for G Protein coupled receptors by means of site-directed spin labeling and pressure modulation EPR spectroscopy
(Applicant
Elgeti, Matthias
)
Investigation of the Membrane Anchor of Human N-Ras by Experimental Approaches, Analytical Models and Molecular Dynamics Simulations
(Applicant
Vogel, Alexander
)
Research Units
Completed projects
FOR 2290: Understanding Intramembrane Proteolysis
(Spokesperson
Langosch, Dieter
)
Investigation of Molecular Dynamics of Substrate Transmembrane alpha-Helices by Solution and Solid-State NMR Spectroscopy
(Applicants
Huster, Daniel
;
Muhle-Goll, Claudia
)
Research Training Groups
Completed projects
GRK 378: Mechanisms and Applications of Non-Conventional Oxidation Reactions
(Spokesperson
Hey-Hawkins, Evamarie
)
Graduate Schools
Completed projects
GSC 185: Leipzig School of Natural Sciences - Building with Molecules and Nano-objects (BuildMoNa)
(Spokesperson
Hey-Hawkins, Evamarie
)
Additional Information
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